硫酸镁治疗重度哮喘的临床证据（附报告一例）_《中国循证医学杂志》

作者：

付娟娟 , 毛兵

四川大学华西临床医学院中西医结合科（成都 610041）;

关键词：

硫酸镁哮喘循证治疗系统评价

DOI：

10.7507/1672-2531.20080243

视频：

导出 下载 收藏 扫码 引用

摘要 全文 图表 视频 参考文献 施引文献 补充材料

目的　对硫酸镁治疗重度哮喘的系统评价进行再评价。
方法　计算机检索Cochrane图书馆（2008 年第2 期）、ACP Journal Club（1991^2008.6）、MEDLINE（1990^2008.6）、中国期刊全文数据库（1979^2008.6）、中文科技期刊全文数据库（VIP）（1980^2008.6）和中国生物医学文献数据库（CBM）（1980^2008.6），查找有关硫酸镁治疗哮喘的系统评价，并进行再评价，将证据应用于临床实践。
结果　共纳入9 篇系统评价，平均包含了QUOROM (thequality of reporting of Meta-analyses) 标准条目中的14.1±2.9 项，质量较高。现有证据表明静脉滴注使用硫酸镁可改善重度哮喘急性发作患者的肺功能，减少入院率，且无严重不良反应；但无足够证据证明吸入和口服硫酸镁对哮喘的治疗作用。我们将上述证据应用于临床，对1 例重度哮喘患者行静脉滴注硫酸镁治疗，该患者哮喘症状控制良好，未发生不良反应。
结论　静脉使用硫酸镁可改善重度哮喘患者的肺功能、降低入院率，安全、有效，应更多地应用于重度哮喘患者的临床治疗。

引用本文： 付娟娟,毛兵. 硫酸镁治疗重度哮喘的临床证据（附报告一例）. 中国循证医学杂志, 2008, 08(12): 1126-1129. doi: 10.7507/1672-2531.20080243 复制

1.	CHINA, Global Strategy for Asthma Management and Prevention: Revised 2006. In: htpp//www.ginasthma.org.
2.	GINA, Global Strategy for Asthma Management and Prevention:.
3.	The Evidence-Based Medicine Working Group. Users’ Guides to the Medical Literature: A Manual for Evidence-Based Clinical Practice. Chicago: AMA Press. 2002.
4.	Phillips B, Ball C, Sackett D, et al. Levels of evidence and grades of recommendation. Available from:URL:http://www.cebm.net/.
5.	Rodrigo G, Rodrigo C, Burschtin O, et al. Efficacy of Magnesium Sulfate in Acute Adult Asthma: A Meta-Analysis of Randomized Trials. Am J Emerg Med, 2000, 18(2): 216-221.
6.	Rowe BH, Bretzlaff JA, Bourdon C, et al. Intravenous Magnesium Sulfate Treatment for Acute Asthma in the Emergency Department: A Systematic Review of the Literature. Ann Emerg Med, 2000, 36(3): 181-190.
7.	Rowe BH, Bretzlaff JA, Bourdon C, et al. Magnesium sulfate for treating exacerbations of acute asthma in the emergency department. Cochrane Database of Systematic Reviews 2000, Issue 1. Art. No.: CD001490.
8.	Cheuk DKL, Chau TCH，Lee SL, et al. A meta-analysis on intravenous magnesium sulphate fortreating acute asthma. Arch Dis Child, 2005, 90: 74-77.
9.	Rowe BH, Camargo CA. The role of magnesium sulfate in the acute and chronic management of asthma. Cur Opin Pulm Med, 2008, 14: 70.
10.	Blitz M, Blitz S, Hughes R, et al. Aerosolized Magnesium Sulfate for Acute Asthma: A Systematic Review. Chest, 2005, 128: 337-344.
11.	Blitz M, Blitz S, Beasely R, et al. Inhaled magnesium sulfate in the treatment of acute asthma. Cochrane Database of Systematic Reviews 2005, Issue 4. Art. No.: CD003898.
12.	鲁晓勇, 周建英. 以不同溶媒雾化吸入沙丁胺醇对哮喘急性发作治疗作用的Meta分析.浙江大学学报 (医学版), 2006, 35(3): 336-341.
13.	Villeneuve EJ, Zed PJ. Nebulized Magnesium Sulfate in the Management of Acute Exacerbations of Asthma. Ann Pharmacother, 2006, 40: 1118-1124.
14.	Moher D, Cook DJ, Eastwood S, et al. Improving the quality of reports of meta-analyses of randomised controlled trials: the QUOROM statement. Lancet, 1999, 354: 1896-1900.

1. CHINA, Global Strategy for Asthma Management and Prevention: Revised 2006. In: htpp//www.ginasthma.org.
2. GINA, Global Strategy for Asthma Management and Prevention:.
3. The Evidence-Based Medicine Working Group. Users’ Guides to the Medical Literature: A Manual for Evidence-Based Clinical Practice. Chicago: AMA Press. 2002.
4. Phillips B, Ball C, Sackett D, et al. Levels of evidence and grades of recommendation. Available from:URL:http://www.cebm.net/.
5. Rodrigo G, Rodrigo C, Burschtin O, et al. Efficacy of Magnesium Sulfate in Acute Adult Asthma: A Meta-Analysis of Randomized Trials. Am J Emerg Med, 2000, 18(2): 216-221.
6. Rowe BH, Bretzlaff JA, Bourdon C, et al. Intravenous Magnesium Sulfate Treatment for Acute Asthma in the Emergency Department: A Systematic Review of the Literature. Ann Emerg Med, 2000, 36(3): 181-190.
7. Rowe BH, Bretzlaff JA, Bourdon C, et al. Magnesium sulfate for treating exacerbations of acute asthma in the emergency department. Cochrane Database of Systematic Reviews 2000, Issue 1. Art. No.: CD001490.
8. Cheuk DKL, Chau TCH，Lee SL, et al. A meta-analysis on intravenous magnesium sulphate fortreating acute asthma. Arch Dis Child, 2005, 90: 74-77.
9. Rowe BH, Camargo CA. The role of magnesium sulfate in the acute and chronic management of asthma. Cur Opin Pulm Med, 2008, 14: 70.
10. Blitz M, Blitz S, Hughes R, et al. Aerosolized Magnesium Sulfate for Acute Asthma: A Systematic Review. Chest, 2005, 128: 337-344.
11. Blitz M, Blitz S, Beasely R, et al. Inhaled magnesium sulfate in the treatment of acute asthma. Cochrane Database of Systematic Reviews 2005, Issue 4. Art. No.: CD003898.
12. 鲁晓勇, 周建英. 以不同溶媒雾化吸入沙丁胺醇对哮喘急性发作治疗作用的Meta分析.浙江大学学报 (医学版), 2006, 35(3): 336-341.
13. Villeneuve EJ, Zed PJ. Nebulized Magnesium Sulfate in the Management of Acute Exacerbations of Asthma. Ann Pharmacother, 2006, 40: 1118-1124.
14. Moher D, Cook DJ, Eastwood S, et al. Improving the quality of reports of meta-analyses of randomised controlled trials: the QUOROM statement. Lancet, 1999, 354: 1896-1900.

《中国循证医学杂志》

硫酸镁治疗重度哮喘的临床证据（附报告一例）

摘要 全文 图表 视频 参考文献 施引文献 补充材料

上一篇

下一篇

Format

Content

《中国循证医学杂志》

硫酸镁治疗重度哮喘的临床证据（附报告一例）

摘要 全文 图表 视频 参考文献 施引文献 补充材料

上一篇

下一篇

Format

Content

摘要全文图表视频参考文献施引文献补充材料