TGF基因多态性与高血压遗传易感性关系的Meta分析_《中国循证医学杂志》

作者：

李敏 ^1,2 ,  时景璞 ^1,2

1. 中国医科大学附属第一医院临床流行病学教研室（沈阳 110001）；2. 辽宁省循证医学中心（沈阳 110001）;

关键词：

转化生长因子基因多态性高血压 Meta分析病例对照研究

DOI：

10.7507/1672-2531.20110235

视频：

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摘要 全文 图表 视频 参考文献 施引文献 补充材料

目的　综合评价转化生长因子β1（transforming growth factor β1，TGF β1）基因869T/C、915G/C多态性与高血压遗传易感性的关系。
方法　按照统一的检索策略，在各大中英文数据库中全面检索相关文献，获取有关TGF β1基因多态性同高血压遗传易感性关系的病例-对照研究，而后按照纳入与排除标准选择文献、提取资料和评价质量后，采用RevMan 5.1软件进行Meta分析。
结果　共纳入14个病例-对照研究。Meta分析结果显示：TGF β1基因869总突变C等位基因与高血压发病相关［OR=1.37，95%CI（1.21，1.54）］。携带CC、TT基因型的个体发生高血压危险性的OR值分别为1.43（1.27，1.60）和0.64（0.53，0.78）。TGF β1基因915G/C多态性与高血压关联无统计学意义。对以中国人群为研究对象的研究进行综合，该两个多态性位点的结果与整体分析结果均相近。敏感性分析显示结果稳定，Begg、Egger检验提示无发表偏倚。
结论　 TGF β1基因869T/C多态性能够增加携带者患高血压的发病风险，C等位基因可能是高血压易感性的标记基因之一，暂未发现TGF β1基因915G/C多态性同高血压发病相关。

引用本文： 李敏,时景璞. TGF基因多态性与高血压遗传易感性关系的Meta分析. 中国循证医学杂志, 2011, 11(12): 1384-1390. doi: 10.7507/1672-2531.20110235 复制

1.	Golbang AP, Murthy M, Hamad A, et al. A new kindred with pseudohypoaldosteronism typeⅡand a novel mutation (564D>H) in the acidic motif of the WNK4 gene. Hypertension, 2005, 56(2): 295-300.
2.	Horwitz RI, Feinstein AR. Methodologic standards and contradictory result in case-control research. Am J Med, 1979, 66(4): 556-564.
3.	Colditz GA, Burdick E, Mosteller F. Heterogeneity in meta-analysis of data from epidemiologic studies: a commentary. Am J Epidemiol, 1995, 142(4): 371-382.
4.	DerSimonian R, Kacker R. Random-effects model for meta-analysis of clinical trials: an update. Contemp Clin Trials, 2007, 28(2): 105-114.
5.	Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics, 1994, 50(4): 1088-1101.
6.	Egger M, Davey Smith G, Schneider M, et al. Bias in meta-analysis detected by a simple, graphical test. BMJ, 1997, 315(7109): 629-634.
7.	He F, Zhao D, Deng F, et al. Association of TGF-beta 1 gene polymorphisms in exon1 and blood levels with essential hypertension. Blood Press, 2010, 19(4): 225-233.
8.	赵丹, 胡清华, 邓峰美, 等. 新疆哈萨克族转化生长因子β1基因多态性及其血浆水平与原发性高血压的关系. 中华医学遗传学杂志, 2010, 27(4): 463-468.
9.	唐任光, 韦叶生, 黄照河. 转化生长因子β1基因+869T/C多态性与原发性高血压的关系. 临床检验杂志, 2009, 27(4): 270-271.
10.	Argano C, Duro G, Corrao S, et al. Transforming growth factor beta1 T29C gene polymorphism and hypertension: relationship with cardiovascular and renal damage. Blood Press, 2008, 17(4): 220-226.
11.	Ivanov VP, Solodilova MA, Polonnikov AV, et al. Arg25Pro polymorphism of transforming growth factor-beta1 and its role in the pathogenesis of essential hypertension in Russian population of Central Chernozem Region. Bull Exp Biol Med, 2007, 114(1): 66-68.
12.	陈慧生, 张七一, 王云英. 转化生长因子β1基因多态性及其血清水平与高血压病肾脏损害的关系. 临床内科杂志, 2007, 24(1): 57-59.
13.	韦常丽, 吴延佳, 邱全, 等. 转化生长因子β1 基因多态性与原发性高血压关系的研究. 中国老年学杂志, 2007, 27(10): 962-964.
14.	呼邦传, 初少莉, 王继光, 等. 三个候选基因多态性与高血压病关联的研究. 中华内科杂志, 2006, 45(4): 281-284.
15.	张七一, 董海, 王云英, 等. 转化生长因子β1 基因多态性及血清水平与高血压左室肥厚的关系. 中华老年医学杂志, 2006, 25(5): 358-360.
16.	韦叶生, 李壮, 蓝景生. 转化生长因子β1基因多态性与广西壮族人原发性高血压的遗传易感性. 第四军医大学学报, 2005, 26(4): 341-344.
17.	Babel N, Cherepnev G, Kowalenko A, et al. Nonimmunologic complications and gene polymorphisms of immunoregulatory cytokines in long-term renal transplants. Kidney Int, 2004, 66(1): 428-432.
18.	Yamada Y, Fujisawa M, Ando F, et al. Association of a polymorphism of the transforming growth factor-beta1 gene with blood pressure in Japanese individuals. J Hum Genet, 2002, 4(5): 243-248.
19.	Frossard PM, Gupta A, Pravica V, et al. A study of five human cytokine genes in human essential hypertension. Mol Immunol, 2001, 38(12-13): 969-976.
20.	Li B, Khanna A, Sharma V, et al. TGF-beta1 DNA polymorphisms, protein levels, and blood pressure. Hypertension, 1999, 33(1Pt2): 271-275.
21.	Cusi D, Barlassina C, Azzani T, et al. Polymorphisms of alpha-adducin and salt sensitivity in patients with essential hypertension. Lancet, 1997, 349(9062): 1353-1357.
22.	Stoll C, Mengsteab S, Stoll D, et al. Analysis of polymorphic TGFβ1 codons 10, 25, and 263 in a German patient group with non-syndromic cleft lip, alveolus, and palate compared with healthy adults. BMC Med Genet, 2004, 5: 15.
23.	Quarmby S, Fakhoury H, Levine E, et al. Association of transforming growth factor beta-1 single nucleotide polymorphisms with radiation-induced damage to normal tissues in breast cancer patients. Int J Radiat Biol, 2003, 79(2): 137-143.
24.	Antonipillai I, Le TH, Soceneantu L, et al. Transforming growth factor-beta is a renin secretagogue at picomolar concentrations. Am J Physiol, 1993, 265(4 Pt 2): F537-541.
25.	Kaizar EE. Metaanalyses are observational studies: how lack of randomization impacts analysis. Am J Gastroenterol, 2005, 100(6): 1233-1236.

1. Golbang AP, Murthy M, Hamad A, et al. A new kindred with pseudohypoaldosteronism typeⅡand a novel mutation (564D>H) in the acidic motif of the WNK4 gene. Hypertension, 2005, 56(2): 295-300.
2. Horwitz RI, Feinstein AR. Methodologic standards and contradictory result in case-control research. Am J Med, 1979, 66(4): 556-564.
3. Colditz GA, Burdick E, Mosteller F. Heterogeneity in meta-analysis of data from epidemiologic studies: a commentary. Am J Epidemiol, 1995, 142(4): 371-382.
4. DerSimonian R, Kacker R. Random-effects model for meta-analysis of clinical trials: an update. Contemp Clin Trials, 2007, 28(2): 105-114.
5. Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics, 1994, 50(4): 1088-1101.
6. Egger M, Davey Smith G, Schneider M, et al. Bias in meta-analysis detected by a simple, graphical test. BMJ, 1997, 315(7109): 629-634.
7. He F, Zhao D, Deng F, et al. Association of TGF-beta 1 gene polymorphisms in exon1 and blood levels with essential hypertension. Blood Press, 2010, 19(4): 225-233.
8. 赵丹, 胡清华, 邓峰美, 等. 新疆哈萨克族转化生长因子β1基因多态性及其血浆水平与原发性高血压的关系. 中华医学遗传学杂志, 2010, 27(4): 463-468.
9. 唐任光, 韦叶生, 黄照河. 转化生长因子β1基因+869T/C多态性与原发性高血压的关系. 临床检验杂志, 2009, 27(4): 270-271.
10. Argano C, Duro G, Corrao S, et al. Transforming growth factor beta1 T29C gene polymorphism and hypertension: relationship with cardiovascular and renal damage. Blood Press, 2008, 17(4): 220-226.
11. Ivanov VP, Solodilova MA, Polonnikov AV, et al. Arg25Pro polymorphism of transforming growth factor-beta1 and its role in the pathogenesis of essential hypertension in Russian population of Central Chernozem Region. Bull Exp Biol Med, 2007, 114(1): 66-68.
12. 陈慧生, 张七一, 王云英. 转化生长因子β1基因多态性及其血清水平与高血压病肾脏损害的关系. 临床内科杂志, 2007, 24(1): 57-59.
13. 韦常丽, 吴延佳, 邱全, 等. 转化生长因子β1 基因多态性与原发性高血压关系的研究. 中国老年学杂志, 2007, 27(10): 962-964.
14. 呼邦传, 初少莉, 王继光, 等. 三个候选基因多态性与高血压病关联的研究. 中华内科杂志, 2006, 45(4): 281-284.
15. 张七一, 董海, 王云英, 等. 转化生长因子β1 基因多态性及血清水平与高血压左室肥厚的关系. 中华老年医学杂志, 2006, 25(5): 358-360.
16. 韦叶生, 李壮, 蓝景生. 转化生长因子β1基因多态性与广西壮族人原发性高血压的遗传易感性. 第四军医大学学报, 2005, 26(4): 341-344.
17. Babel N, Cherepnev G, Kowalenko A, et al. Nonimmunologic complications and gene polymorphisms of immunoregulatory cytokines in long-term renal transplants. Kidney Int, 2004, 66(1): 428-432.
18. Yamada Y, Fujisawa M, Ando F, et al. Association of a polymorphism of the transforming growth factor-beta1 gene with blood pressure in Japanese individuals. J Hum Genet, 2002, 4(5): 243-248.
19. Frossard PM, Gupta A, Pravica V, et al. A study of five human cytokine genes in human essential hypertension. Mol Immunol, 2001, 38(12-13): 969-976.
20. Li B, Khanna A, Sharma V, et al. TGF-beta1 DNA polymorphisms, protein levels, and blood pressure. Hypertension, 1999, 33(1Pt2): 271-275.
21. Cusi D, Barlassina C, Azzani T, et al. Polymorphisms of alpha-adducin and salt sensitivity in patients with essential hypertension. Lancet, 1997, 349(9062): 1353-1357.
22. Stoll C, Mengsteab S, Stoll D, et al. Analysis of polymorphic TGFβ1 codons 10, 25, and 263 in a German patient group with non-syndromic cleft lip, alveolus, and palate compared with healthy adults. BMC Med Genet, 2004, 5: 15.
23. Quarmby S, Fakhoury H, Levine E, et al. Association of transforming growth factor beta-1 single nucleotide polymorphisms with radiation-induced damage to normal tissues in breast cancer patients. Int J Radiat Biol, 2003, 79(2): 137-143.
24. Antonipillai I, Le TH, Soceneantu L, et al. Transforming growth factor-beta is a renin secretagogue at picomolar concentrations. Am J Physiol, 1993, 265(4 Pt 2): F537-541.
25. Kaizar EE. Metaanalyses are observational studies: how lack of randomization impacts analysis. Am J Gastroenterol, 2005, 100(6): 1233-1236.

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TGF基因多态性与高血压遗传易感性关系的Meta分析

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TGF基因多态性与高血压遗传易感性关系的Meta分析

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