• 成都市婦產(chǎn)科醫(yī)院（成都，610015）;

【摘要】　目的　 探討甲氨蝶呤(MTX)聯(lián)合米非司酮治療早期異位妊娠(EP)的臨床效果。　方法　 收集2006年2月-2010年2月收治的早期未破裂型EP患者126例，隨機(jī)分為MTX聯(lián)合米非司酮組62例，單獨(dú)應(yīng)用MTX組64例， MTX治療采用小劑量分次肌肉注射給藥進(jìn)行。　結(jié)果　 126例患者中，MTX聯(lián)合米非司酮組和單獨(dú)應(yīng)用MTX治療組的成功率為分別為88%和65%，兩組差異有統(tǒng)計學(xué)意義(P lt;0.05)。　結(jié)論　 MTX小劑量分次給藥聯(lián)合米非司酮治療早期未破裂型EP效果優(yōu)于MTX的單獨(dú)使用。
【Abstract】　Objective　 To observe the therapeutic effect of methotrexate (MTX) combined with mifepristone on early ectopic pregnancy.　Methods　 A total of 126 patients with early ectopic pregnancy diagnosed from February 2006 to Febrary 2010 were randomly divided into two groups. In 126 patients, 62 treated with MTX combined with mifepristone were in the treatment group,and 64 treated independently with MTX were in the control group. MTX was administrated at a low dose in several times.　Results　 In 126 patients,the success ratio of the treatment was 88% in treatment group groups and 65% in the control group; the difference between the two groups was significant (P lt;0.05).　Conclusion　 Low-dose MTX in separate times combined with mifepriston is effective on the early ectopic pregnancy, and the therapeutic effect of the combined administration of MTX and mifepriston is better than that of the single administration with MTX.

引用本文： 周萍,王濤. 甲氨蝶呤小劑量分次給藥聯(lián)合米非司酮治療早期異位妊娠的臨床研究. 華西醫(yī)學(xué), 2010, 25(12): 2231-2233. doi: 復(fù)制

1. 　Condous G. Ectopic pregnancy: challenging accepted management strategies[J]. Aust N Z J Obstet Gynaecol, 2009, 49(4): 346-351.
2. 　蔣鳳艷, 龍鳳宜. 氨甲喋呤聯(lián)合米非司酮治療異位妊娠療效觀察[J]. 廣西醫(yī)科大學(xué)學(xué)報, 2001, 18(3): 349-351.
3. 　李志凌, 左緒磊, 陳滌瑕. 氨甲喋呤單次肌肉注射治療異位妊娠適應(yīng)證和檢測指標(biāo)的研究[J]. 實(shí)用婦產(chǎn)科雜志, 1999, 15(6): 305.
4. 　Stovall TG, Ling FW. Single close methotexate: an expancled clinical trial[J]. Am J Obstet Gynecol, 1993, 168(6): 1759.
5. 　樂杰. 婦產(chǎn)科學(xué) [M]　 . 6版. 北京: 人民衛(wèi)生出版社, 2004: 111-113.
6. 　Raine-Fenning N, Hopkisson J. Management of ectopic pregnancy: a clinical approach [J]　 . Obstet Gynaecol Repro Med, 2009, 19(1): 19-25.
7. 　趙輝, 楊保軍, 馮力民. 宮腔鏡下輸卵管注射甲氨蝶呤與口服米非司酮聯(lián)用在輸卵管妊娠保守治療中的應(yīng)用[J]. 中國醫(yī)學(xué)科學(xué)院學(xué)報, 2010, 32(3): 315-319.
8. 　Amso NN, Stabinsky SA, McFaul P, et al. Uterine thermal balloon therapy for the treatment of menorrhagia: the first 300 patients from amul-ticentre study[J]. Br J Obstet Gynaeco, 1998, 105(5): 517.
9. 　Branhar K, Coutifaris C, Esposito M. The harmacology of methotrexate[J]. Exper Opin Pharmacother, 2001, 2(3): 409-417.
  1. 1. 　Condous G. Ectopic pregnancy: challenging accepted management strategies[J]. Aust N Z J Obstet Gynaecol, 2009, 49(4): 346-351.
  2. 2. 　蔣鳳艷, 龍鳳宜. 氨甲喋呤聯(lián)合米非司酮治療異位妊娠療效觀察[J]. 廣西醫(yī)科大學(xué)學(xué)報, 2001, 18(3): 349-351.
  3. 3. 　李志凌, 左緒磊, 陳滌瑕. 氨甲喋呤單次肌肉注射治療異位妊娠適應(yīng)證和檢測指標(biāo)的研究[J]. 實(shí)用婦產(chǎn)科雜志, 1999, 15(6): 305.
  4. 4. 　Stovall TG, Ling FW. Single close methotexate: an expancled clinical trial[J]. Am J Obstet Gynecol, 1993, 168(6): 1759.
  5. 5. 　樂杰. 婦產(chǎn)科學(xué) [M]　 . 6版. 北京: 人民衛(wèi)生出版社, 2004: 111-113.
  6. 6. 　Raine-Fenning N, Hopkisson J. Management of ectopic pregnancy: a clinical approach [J]　 . Obstet Gynaecol Repro Med, 2009, 19(1): 19-25.
  7. 7. 　趙輝, 楊保軍, 馮力民. 宮腔鏡下輸卵管注射甲氨蝶呤與口服米非司酮聯(lián)用在輸卵管妊娠保守治療中的應(yīng)用[J]. 中國醫(yī)學(xué)科學(xué)院學(xué)報, 2010, 32(3): 315-319.
  8. 8. 　Amso NN, Stabinsky SA, McFaul P, et al. Uterine thermal balloon therapy for the treatment of menorrhagia: the first 300 patients from amul-ticentre study[J]. Br J Obstet Gynaeco, 1998, 105(5): 517.
  9. 9. 　Branhar K, Coutifaris C, Esposito M. The harmacology of methotrexate[J]. Exper Opin Pharmacother, 2001, 2(3): 409-417.