• 1四川省成都市第二人民醫(yī)院心內(nèi)科，四川成都 610017;2第三軍醫(yī)大學(xué)西南醫(yī)院老年科，重慶 400038;

目的：采用常壓間歇性低氧(intermittent hypoxia,IH)大鼠的動(dòng)物模型，觀察間歇性常壓低氧預(yù)處理的促血管生成作用。方法:成年雄性Wistar大鼠25只，體重210～215 g，隨機(jī)分為2大組:對(duì)照組(C組，n=5)和間歇性低氧預(yù)處理組(IH組，n=20)。IH組動(dòng)物進(jìn)行間歇性低氧預(yù)處理(4 h/d，間歇缺氧1 d者為IH1組，7 d者為IH2組，14 d者為IH3組，28 d者為IH4組)，按計(jì)劃完成實(shí)驗(yàn)后測(cè)定心肌血管內(nèi)皮生長因子(VEGF) 蛋白表達(dá)及毛細(xì)血管密度。結(jié)果：間歇性低氧預(yù)處理大鼠心肌VEGF蛋白表達(dá)增加，心肌毛細(xì)血管密度增高。結(jié)論：間歇性低氧預(yù)處理能促進(jìn)大鼠心肌內(nèi)的血管生成，其機(jī)制可能與心肌VEGF表達(dá)增高有關(guān)。

引用本文： 張文勇,王璋,李秋,趙思勤,聶曉莉,胡詠梅. 間歇性低氧預(yù)處理對(duì)大鼠心肌促血管生成作用的實(shí)驗(yàn)研究. 華西醫(yī)學(xué), 2008, 23(1): 108-109. doi: 復(fù)制

版權(quán)信息： ?四川大學(xué)華西醫(yī)院華西期刊社《華西醫(yī)學(xué)》版權(quán)所有，未經(jīng)授權(quán)不得轉(zhuǎn)載、改編

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