• 川北醫(yī)學院第二臨床醫(yī)學院胃腸外科（四川南充 637000）;

目的 　總結(jié)非甾體類抗炎藥抗腫瘤機理的研究進展。
方法 　查閱近年來國內(nèi)外關(guān)于非甾體類抗炎藥抗腫瘤機理的相關(guān)文獻，就其研究進展進行綜述。
結(jié)果 　非甾體類抗炎藥抗腫瘤的機理是多層次、多位點的。
結(jié)論 　非甾體類抗炎藥有望成為結(jié)直腸癌高危人群的預防用藥和結(jié)直腸癌根治術(shù)后的化療輔助用藥，用于預防術(shù)后腫瘤的復發(fā)。

引用本文： 李權(quán)林,任明揚. 非甾體類抗炎藥抗腫瘤機理的研究進展. 中國普外基礎(chǔ)與臨床雜志, 2012, 19(12): 1368-1371. doi: 復制

1. Ruder EH， Laiyemo AO， Graubard BI， et al. Non-steroidal anti-inflammatory drugs and colorectal cancer risk in a large， prospective cohort[J]. Am J Gastroenterol， 2011， 106(7)：1340-1350.
2. Coghill AE， Newcomb PA， Campbell PT， et al. Prediagnostic non-steroidal anti-inflammatory drug use and survival after diagnosis of colorectal cancer[J]. Gut， 2011， 60(4)：491-498.
3. Burn J， Bishop DT， Chapman PD， et al. A randomized placebo-controlled prevention trial of aspirin and/or resistant starch in young people with familial adenomatous polyposis[J]. Cancer Prev Res (Phila)， 2011， 4(5)：655-665.
4. Liao LM， Vaughan TL， Corley DA， et al. Nonsteroidal anti-inflammatory drug use reduces risk of adenocarcinomas of the esophagus and esophagogastric junction in a pooled analysis[J]. Gastroenterology， 2012， 142(3)： 442-452.
5. Mccormack VA， Hung RJ， Brenner DR， et al. Aspirin and NSAID use and lung cancer risk： a pooled analysis in the International Lung Cancer Consortium (ILCCO)[J]. Cancer Causes Control， 2011， 22(12)： 1709-1720.
6. Mahmud SM， Franco EL， Turner D， et al. Use of non-steroidal anti-inflammatory drugs and prostate cancer risk： a population-based nested case-control study[J]. PLoS One， 2011， 6(1)： e16412.
7. Takkouche B， Regueira-Méndez C， Etminan M. Breast Cancer and use of nonsteroidal anti-inflammatory drugs： a meta-analysis[J]. J Natl Cancer Inst， 2008， 100(20)： 1439-1447.
8. Hossain MA， Kim DH， Jang JY， et al. Aspirin induces apoptosisin vitro and inhibits tumor growth of human hepatocellular carcinoma cells in a nude mouse xenograft model[J]. Int J Oncol， 2012， 40(4)： 1298-1304.
9. Tomoda C， Moatamed F， Naeim F， et al. Indomethacin inhibits cell growth of medullary thyroid carcinoma by reducing cell cycle progression into S phase[J]. Exp Biol Med， 2008， 233(11)： 1433-1440.
10. Ghosh N， Chaki R， Mandal V， et al. COX-2 as a target for cancerchemotherapy[J]. Pharmacol Rep， 2010， 62(2)：233-244.
11. Chen XL， Su BS， Sun RQ， et al. Relationship between expression and distribution of cyclooxygenase-2 and bcl-2 in humangastric adenocarcinoma[J]. World J Gastroenterol， 2005， 11(8)：1228-1231.
12. Kim BH， Kim CI， Chang HS， et al. Cyclooxygenase-2 overexpression in chronic inflammation associated with benign prostatic hyperplasia：is it related to apoptosis and angiogenesis of prostate cancer?[J]. Korean J Urol， 2011， 52(4)：253-259.
13. Leung E， McArthur D， Morris A， et al. Cyclooxygenase-2 inhibition prevents migration of colorectal cancer cells to extracellular matrix by down-regulation of matrix metalloproteinase-2 expression[J]. Dis Colon Rectum， 2008， 51(3)：342-347.
14. Fang C， Bourdette D， Banker G， et al. Oxidative stress inhibits axonal transport：implication for neurodegenerative diseases[J]. Mol Neurodegener， 2012， 7： 29.
15. Wang Y， Yu Q， Fan D， et al. Coronary heart disease in Type 2 diabetes： mechanisms and comprehensive prevention strategies[J]. Expert Rev Cardiovasc Ther， 2012， 10(8)： 1051-1060.
16. Chen W， Zhu H， Jia ZQ， et al. Inhibition of peroxynitrite-mediated DNA strand cleavage and hydroxyl radical formation by aspirin at pharmacologically relevant concentrations：implications for cancer intervention[J]. Biochem Biophys Res Commun， 2009， 390(1)：142-147.
17. Goel A， Chang DK， Ricciardiello L， et al. A novel mechanism for aspirin-mediated growth inhibition of human colon cancer cells[J]. Clin Cancer Res， 2003， 9(1)：383-390.
18. Dibra HK， Brown JE， Hooley P， et al. Aspirin and alterations in DNA repair proteins in the SW480 colorectal cancer cell line[J]. Oncol Rep， 2010， 24(1)：37-46.
19. He H， Xia HH， Wang JD， et al. Inhibition of human telomerase reverse transcriptase by nonsteroidal antiinflammatory drugs in colon carcinoma[J]. Cancer， 2006， 106(6)：1243-1249.
20. Raza H， John A， Benedict S. Acetylsalicylic acid-induced oxidative stress， cell cycle arrest， apoptosis and mitochondrialdysfunction in human hepatoma HepG2 cells[J]. Eur J Pharmacol，2011， 668(1-2)：15-24.
21. Bank A， Yu J， Zhang L. NSAIDs downregulate bcl-X(L) and dissociate BAX and bcl-X(L) to induce apoptosis in colon cancer cells[J]. Nutr Cancer， 2008， 60(Suppl 1)：98-103.
22. Liu HF， Hsiao PW， Chao JI. Celecoxib induces p53-PUMA pathway for apoptosis in human colorectal cancer cells[J]. Chem Biol Interact， 2008， 176(1)：48-57.
23. Uddin S， Ahmed M， Hussain A， et al. Cyclooxygenase-2 inhibition inhibits PI3K/AKT kinase activity in epithelial ovarian cancer[J]. Int J Cancer， 2010， 126(2)：382-394.
24. Zhang ZQ， Huang LQ， Zhao WP， et al. Annexin 1 induced by anti-inflammatory drugs binds to NF-κB inhibiting its activation：anticancer effects in vitro and in vivo[J]. Cancer Res， 2010， 70(6)：2379-2388.
25. Chattopadhyay M， Goswami S， Rodes DB， et al. No-releasing NSAIDs suppress NF-κB signaling in vitro and in vivo throughS-nitrosylation[J]. Cancer Lett， 2010， 298(2)：204-211.
26. Tinsley HN， Gary BD， Thaiparambil J， et al. Colon tumor cell growth-inhibitory activity of sulindac sulfide and other nonsteroidal anti-inflammatory drugs is associated with phosphodiesterase 5 inhibition[J]. Cancer Prev Res (Phila)， 2010， 3(10)：1303-1313.
27. Brunelli C， Amici C， Angelini M， et al. The non-steroidal anti-inflammatory drug indomethacin activates the eIF2α kinase PKR， causing a translational block in human colorectal cancer cells[J]. Biochem J， 2012， 443(2)：379-386.
28. Réti A， Pap E， Adleff V， et al. Enhanced 5-fluorouracil cytotoxicity in high cyclooxygenase-2 expressing colorectal cancer cells and xenografts induced by non-steroidal anti-inflammatory drugs via downregulation of dihydropyrimidine dehydrogenase[J]. Cancer Chemother Pharmacol， 2010， 66(2)：219-227.
  1. 1. Ruder EH， Laiyemo AO， Graubard BI， et al. Non-steroidal anti-inflammatory drugs and colorectal cancer risk in a large， prospective cohort[J]. Am J Gastroenterol， 2011， 106(7)：1340-1350.
  2. 2. Coghill AE， Newcomb PA， Campbell PT， et al. Prediagnostic non-steroidal anti-inflammatory drug use and survival after diagnosis of colorectal cancer[J]. Gut， 2011， 60(4)：491-498.
  3. 3. Burn J， Bishop DT， Chapman PD， et al. A randomized placebo-controlled prevention trial of aspirin and/or resistant starch in young people with familial adenomatous polyposis[J]. Cancer Prev Res (Phila)， 2011， 4(5)：655-665.
  4. 4. Liao LM， Vaughan TL， Corley DA， et al. Nonsteroidal anti-inflammatory drug use reduces risk of adenocarcinomas of the esophagus and esophagogastric junction in a pooled analysis[J]. Gastroenterology， 2012， 142(3)： 442-452.
  5. 5. Mccormack VA， Hung RJ， Brenner DR， et al. Aspirin and NSAID use and lung cancer risk： a pooled analysis in the International Lung Cancer Consortium (ILCCO)[J]. Cancer Causes Control， 2011， 22(12)： 1709-1720.
  6. 6. Mahmud SM， Franco EL， Turner D， et al. Use of non-steroidal anti-inflammatory drugs and prostate cancer risk： a population-based nested case-control study[J]. PLoS One， 2011， 6(1)： e16412.
  7. 7. Takkouche B， Regueira-Méndez C， Etminan M. Breast Cancer and use of nonsteroidal anti-inflammatory drugs： a meta-analysis[J]. J Natl Cancer Inst， 2008， 100(20)： 1439-1447.
  8. 8. Hossain MA， Kim DH， Jang JY， et al. Aspirin induces apoptosisin vitro and inhibits tumor growth of human hepatocellular carcinoma cells in a nude mouse xenograft model[J]. Int J Oncol， 2012， 40(4)： 1298-1304.
  9. 9. Tomoda C， Moatamed F， Naeim F， et al. Indomethacin inhibits cell growth of medullary thyroid carcinoma by reducing cell cycle progression into S phase[J]. Exp Biol Med， 2008， 233(11)： 1433-1440.
  10. 10. Ghosh N， Chaki R， Mandal V， et al. COX-2 as a target for cancerchemotherapy[J]. Pharmacol Rep， 2010， 62(2)：233-244.
  11. 11. Chen XL， Su BS， Sun RQ， et al. Relationship between expression and distribution of cyclooxygenase-2 and bcl-2 in humangastric adenocarcinoma[J]. World J Gastroenterol， 2005， 11(8)：1228-1231.
  12. 12. Kim BH， Kim CI， Chang HS， et al. Cyclooxygenase-2 overexpression in chronic inflammation associated with benign prostatic hyperplasia：is it related to apoptosis and angiogenesis of prostate cancer?[J]. Korean J Urol， 2011， 52(4)：253-259.
  13. 13. Leung E， McArthur D， Morris A， et al. Cyclooxygenase-2 inhibition prevents migration of colorectal cancer cells to extracellular matrix by down-regulation of matrix metalloproteinase-2 expression[J]. Dis Colon Rectum， 2008， 51(3)：342-347.
  14. 14. Fang C， Bourdette D， Banker G， et al. Oxidative stress inhibits axonal transport：implication for neurodegenerative diseases[J]. Mol Neurodegener， 2012， 7： 29.
  15. 15. Wang Y， Yu Q， Fan D， et al. Coronary heart disease in Type 2 diabetes： mechanisms and comprehensive prevention strategies[J]. Expert Rev Cardiovasc Ther， 2012， 10(8)： 1051-1060.
  16. 16. Chen W， Zhu H， Jia ZQ， et al. Inhibition of peroxynitrite-mediated DNA strand cleavage and hydroxyl radical formation by aspirin at pharmacologically relevant concentrations：implications for cancer intervention[J]. Biochem Biophys Res Commun， 2009， 390(1)：142-147.
  17. 17. Goel A， Chang DK， Ricciardiello L， et al. A novel mechanism for aspirin-mediated growth inhibition of human colon cancer cells[J]. Clin Cancer Res， 2003， 9(1)：383-390.
  18. 18. Dibra HK， Brown JE， Hooley P， et al. Aspirin and alterations in DNA repair proteins in the SW480 colorectal cancer cell line[J]. Oncol Rep， 2010， 24(1)：37-46.
  19. 19. He H， Xia HH， Wang JD， et al. Inhibition of human telomerase reverse transcriptase by nonsteroidal antiinflammatory drugs in colon carcinoma[J]. Cancer， 2006， 106(6)：1243-1249.
  20. 20. Raza H， John A， Benedict S. Acetylsalicylic acid-induced oxidative stress， cell cycle arrest， apoptosis and mitochondrialdysfunction in human hepatoma HepG2 cells[J]. Eur J Pharmacol，2011， 668(1-2)：15-24.
  21. 21. Bank A， Yu J， Zhang L. NSAIDs downregulate bcl-X(L) and dissociate BAX and bcl-X(L) to induce apoptosis in colon cancer cells[J]. Nutr Cancer， 2008， 60(Suppl 1)：98-103.
  22. 22. Liu HF， Hsiao PW， Chao JI. Celecoxib induces p53-PUMA pathway for apoptosis in human colorectal cancer cells[J]. Chem Biol Interact， 2008， 176(1)：48-57.
  23. 23. Uddin S， Ahmed M， Hussain A， et al. Cyclooxygenase-2 inhibition inhibits PI3K/AKT kinase activity in epithelial ovarian cancer[J]. Int J Cancer， 2010， 126(2)：382-394.
  24. 24. Zhang ZQ， Huang LQ， Zhao WP， et al. Annexin 1 induced by anti-inflammatory drugs binds to NF-κB inhibiting its activation：anticancer effects in vitro and in vivo[J]. Cancer Res， 2010， 70(6)：2379-2388.
  25. 25. Chattopadhyay M， Goswami S， Rodes DB， et al. No-releasing NSAIDs suppress NF-κB signaling in vitro and in vivo throughS-nitrosylation[J]. Cancer Lett， 2010， 298(2)：204-211.
  26. 26. Tinsley HN， Gary BD， Thaiparambil J， et al. Colon tumor cell growth-inhibitory activity of sulindac sulfide and other nonsteroidal anti-inflammatory drugs is associated with phosphodiesterase 5 inhibition[J]. Cancer Prev Res (Phila)， 2010， 3(10)：1303-1313.
  27. 27. Brunelli C， Amici C， Angelini M， et al. The non-steroidal anti-inflammatory drug indomethacin activates the eIF2α kinase PKR， causing a translational block in human colorectal cancer cells[J]. Biochem J， 2012， 443(2)：379-386.
  28. 28. Réti A， Pap E， Adleff V， et al. Enhanced 5-fluorouracil cytotoxicity in high cyclooxygenase-2 expressing colorectal cancer cells and xenografts induced by non-steroidal anti-inflammatory drugs via downregulation of dihydropyrimidine dehydrogenase[J]. Cancer Chemother Pharmacol， 2010， 66(2)：219-227.