目的 檢測組織因子（TF）在肝癌組織中的表達并探討其臨床意義。方法 采用RT-PCR方法檢測肝癌、癌旁及對照組肝組織（各27例）中TF mRNA的表達，并結(jié)合臨床病理資料進行分析。結(jié)果 TF在肝癌組織中的表達陽性率及相對表達強度分別為62.96%（17/27）和0.567±0.268，均較癌旁組織的33.33%(9/27)和0.469±0.184及對照組肝組織的29.63%(8/27)和0.353±0.121高（P＜0.05），其相對表達強度與腫瘤大小、肝內(nèi)和肝外轉(zhuǎn)移及門靜脈癌栓有關(guān)（P＜0.05），而與患者性別、AFP、HBsAg、是否合并肝硬變、腫瘤分化程度、癌灶數(shù)目、包膜浸潤及淋巴轉(zhuǎn)移均無關(guān)(P＞0.05)。結(jié)論 TF在肝癌組織中的表達升高與部分侵襲轉(zhuǎn)移指標(biāo)有關(guān)，提示其可能參與了肝細胞癌的發(fā)生及侵襲、轉(zhuǎn)移。
引用本文： 周奇,梁力建,彭寶崗,甄宇洋. 組織因子 mRNA在肝癌患者組織中表達升高的意義. 中國普外基礎(chǔ)與臨床雜志, 2006, 13(6): 698-701. doi: 復(fù)制
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