• 1.陜西省人民醫(yī)院肝膽外科(西安710068);;
  • 2.西安交通大學(xué)第一醫(yī)院肝膽外科（西安710061）;

肝癌中HSP90α的表達(dá)及意義孫水平1吳勝利2耿智敏2牛新捷2楊威2
【摘要】目的研究熱休克蛋白90α（HSP90α）在人肝細(xì)胞性肝癌（HCC）組織中的表達(dá)，并探討其與腫瘤生物學(xué)行為及預(yù)后的關(guān)系。方法采用免疫組織化學(xué)方法檢測(cè)10例正常肝組織、40例HCC組織及其癌旁組織中HSP90α的表達(dá)。結(jié)果HSP90α在正常肝臟、癌旁組織及肝細(xì)胞性肝癌中的表達(dá)陽(yáng)性率分別為10.0%、52.5%及72.5%，在肝細(xì)胞性肝癌中的表達(dá)陽(yáng)性率明顯高于正常肝組織和癌旁組織（P＜0.05）。HCC 的HSP90α陽(yáng)性表達(dá)與腫瘤的臨床分期、分化程度、累及漿膜狀況及淋巴結(jié)轉(zhuǎn)移狀況顯著相關(guān)（P＜0.05）； 而與腫瘤數(shù)目無(wú)關(guān)（P gt;0.05）。HSP90α陰性表達(dá)者的預(yù)后顯著優(yōu)于HSP90α陽(yáng)性表達(dá)者，術(shù)后平均無(wú)瘤生存期前者為38.6個(gè)月，后者為25.5個(gè)月（P＜0.05）。結(jié)論HSP90α在肝細(xì)胞性肝癌中的表達(dá)明顯增強(qiáng)，HSP90α表達(dá)與HCC的臨床分期、腫瘤分化程度、累及漿膜狀況及淋巴結(jié)轉(zhuǎn)移狀況有關(guān)，可作為判斷預(yù)后的指標(biāo)之一。

引用本文： 孫水平,吳勝利,耿智敏,牛新捷,楊威. 肝細(xì)胞肝癌中HSP90α的表達(dá)及意義. 中國(guó)普外基礎(chǔ)與臨床雜志, 2003, 10(3): 243-245. doi: 復(fù)制

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  1. 1. Mizushima Y, Wang P, Jarrar D, et al. Preinduction of heat shock proteins protects cardiac and hepatic functions following trauma and hemorrhage [J]. Am J Physiol Regul Integr Comp Physiol，2000; 278(2)∶R352.
  2. 2. 華赟鵬，梁力建，黃潔夫. 熱休克蛋白與肝缺血再灌注損傷 [J]. 中國(guó)普外基礎(chǔ)與臨床雜志， 2000; 7(4)∶269.
  3. 3. Hartl FU. Molecular chaperones in cellular protein folding [J]. Nature, 1996; 381(6583)∶571.
  4. 4. Kapitanovic M. Mechanical ileus caused by strangulation of the small intestine in a left paraduodenal hernia and in a defect in the root of the mesentery [J]. Lijec Vjesn, 1989； 111(12)∶454.
  5. 5. Yano M, Naito Z, Tanaka S, et al. Expression and roles of heat shock proteins in human breast cancer [J]. Jpn J Cancer Res, 1996; 87(9)∶ 908.
  6. 6. Blagosklonny MV, Toretsky J, Bohen S, et al. Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90 [J]. Proc Natl Acad Sci USA, 1996; 93(16)∶8379.
  7. 7. 黃常志，周純，趙玫，等. 反義熱休克蛋白90 β對(duì)HeLa細(xì)胞惡性表型和藥敏感性的影響 [J]. 中華腫瘤雜志， 2000; 22(1)∶14.
  8. 8. Jameel A, Skilton RA, Campbell TA, et al. Clinical and biological significance of HSP90α in human breast cancer [J]. Int J Cancer, 1992; 50(3)∶409.
  9. 9. Mileo AM, Fanuele M, Battaglia F, et al. Selective overexpression of mRNA coding for 90 kDa stress protein in human ovarian cancer [J]. Anticancer Res, 1990; 10(4)∶903.
  10. 10. Nanbu K, Konishi I, Komatsu T, et al. Expression of heat shock proteins HSP70 and HSP90 in endometrial carcinomas. Correlation with clinicopathology, sex steroid receptor status, and p53 protein expression [J]. Cancer, 1996; 77(2)∶330.