• 第三軍醫(yī)大學附屬第一醫(yī)院普通外科(重慶 400038);

目的  觀察乳腺良性疾病不典型增生癌變過程中基底膜的變化。
方法 采用SP免疫組化染色法和兩種特殊染色方法(Foot及PAS染色法)，并利用電鏡觀察基底膜的變化。
結果  Ⅱ級不典型增生的乳腺組織已有基底膜的變化，Ⅲ級不典型增生時基底膜的變化更明顯，主要表現為光鏡下基底膜明顯厚薄不均，電鏡下則可見小的缺失，而乳腺癌組織中基底膜完全缺如。
結論  在乳腺上皮細胞癌變過程中基底膜的變化與乳腺上皮細胞的變化密切相關，是乳腺上皮不典型增生癌變過程的一部分。

引用本文： 韓曉蓉,姜軍,馬宏敏. 乳腺不典型增生癌變過程中基底膜的變化. 中國普外基礎與臨床雜志, 2001, 8(2): 75-77. doi: 復制

版權信息： ?四川大學華西醫(yī)院華西期刊社《中國普外基礎與臨床雜志》版權所有，未經授權不得轉載、改編

1. Page DL. Cancer risk assessment in benign breast biopsies [J]. Human Pathol, 1986; 17(2A3)∶871.
2. 龔志錦，詹钅容洲.病理組織制片和染色技術[M].上海：上海科學技術出版社，1994：75.
3. Weaver VM, Fischer AH, Peterson OW, et al. The importance of the microenvironment in breast cancer progression:recapitulation of mammary tumorigenesis using a unique human mammary epithelial cell model and a threedimensional culture assay [J]. Biochem Cell Biol, 1996; 74(6)∶833.
4. Liotta A. Cancer cell invasion and metastasis [J]. Scientific Am, 1992; 266(2)∶34.
5. Werb Z, Ashkenas J, MacAuley A. et al. Extracellular matrix remodeling as a regulator of stromalepithelial interactions during mammary gland development, involution and carcinogenesis [J]. Braz J Med Biol Res, 1996; 29(9)∶1087.
6. Madan AK, Yu K, Dhurandhar N, et al. Association of hyaluronidase and breast adenocarcinoma invasiveness [J]. Oncol Rep 1999; 6(3)∶607.
7. 姜軍，詹新恩，陳意生等.乳腺上皮不典型增生時DNA含量、超微結構及腫瘤相關抗原變化的意義 [J].中國普外基礎與臨床雜志，1998； 5(4)∶208.
8. Flug M, Kopf Maier P. The basement membrane and its involvement in carcinoma cell invasion [J]. Acta Anat Bassel, 1995; 152(2)∶69.
  1. 1. Page DL. Cancer risk assessment in benign breast biopsies [J]. Human Pathol, 1986; 17(2A3)∶871.
  2. 2. 龔志錦，詹钅容洲.病理組織制片和染色技術[M].上海：上?？茖W技術出版社，1994：75.
  3. 3. Weaver VM, Fischer AH, Peterson OW, et al. The importance of the microenvironment in breast cancer progression:recapitulation of mammary tumorigenesis using a unique human mammary epithelial cell model and a threedimensional culture assay [J]. Biochem Cell Biol, 1996; 74(6)∶833.
  4. 4. Liotta A. Cancer cell invasion and metastasis [J]. Scientific Am, 1992; 266(2)∶34.
  5. 5. Werb Z, Ashkenas J, MacAuley A. et al. Extracellular matrix remodeling as a regulator of stromalepithelial interactions during mammary gland development, involution and carcinogenesis [J]. Braz J Med Biol Res, 1996; 29(9)∶1087.
  6. 6. Madan AK, Yu K, Dhurandhar N, et al. Association of hyaluronidase and breast adenocarcinoma invasiveness [J]. Oncol Rep 1999; 6(3)∶607.
  7. 7. 姜軍，詹新恩，陳意生等.乳腺上皮不典型增生時DNA含量、超微結構及腫瘤相關抗原變化的意義 [J].中國普外基礎與臨床雜志，1998； 5(4)∶208.
  8. 8. Flug M, Kopf Maier P. The basement membrane and its involvement in carcinoma cell invasion [J]. Acta Anat Bassel, 1995; 152(2)∶69.