通過對20只大鼠小腸缺血再灌注模型血和腎組織中脂質(zhì)過氧化物的測定，并結(jié)合病理改變，以探討小腸缺血再灌注后腎損傷的病理機(jī)理。結(jié)果表明：大鼠小腸缺血再灌注后，血脂質(zhì)過氧化物明顯升高(Ｐ＜0.01)，同時腎組織勻漿內(nèi)脂質(zhì)過氧物明顯高于對照組(Ｐ＜0.01)。提示小腸缺血再灌注后腎組織細(xì)胞確有明顯損傷，其中氧自由基對腎組織的破壞可能是腎臟病理生理改變的主要因素。
引用本文： 鄒揚(yáng),林擎天. 大鼠小腸缺血再灌注后腎臟損傷. 中國普外基礎(chǔ)與臨床雜志, 1999, 6(1): 11-12. doi: 復(fù)制
版權(quán)信息： ?四川大學(xué)華西醫(yī)院華西期刊社《中國普外基礎(chǔ)與臨床雜志》版權(quán)所有，未經(jīng)授權(quán)不得轉(zhuǎn)載、改編
| 1. | Yagi K. Assay for blood plasma or serum lipid peroxides.Methods Enzymol, 1984; 105(4)∶328. |
| 2. | Caty MG, Schmeling DJ, Freid HP, et al. A promoter of xanthire oxidase activity in intestinal ischemia/reperfusion. J Pediatr Surg, 1990; 25(2)∶218. |
| 3. | Schoenberg MH, Beger HG. Reperfusion injury after intestinal ischemia. Critical Care Medicine, 1993; 21(9)∶1376. |
| 4. | Schoenberg MH, Fredholm BB, Haglund U, et al. Studies on the oxygen radical mechanism involved in the small intestinal reperfusion damage. Acta Physiol Scand, 1985; 124(4)∶581. |
- 1. Yagi K. Assay for blood plasma or serum lipid peroxides.Methods Enzymol, 1984; 105(4)∶328.
- 2. Caty MG, Schmeling DJ, Freid HP, et al. A promoter of xanthire oxidase activity in intestinal ischemia/reperfusion. J Pediatr Surg, 1990; 25(2)∶218.
- 3. Schoenberg MH, Beger HG. Reperfusion injury after intestinal ischemia. Critical Care Medicine, 1993; 21(9)∶1376.
- 4. Schoenberg MH, Fredholm BB, Haglund U, et al. Studies on the oxygen radical mechanism involved in the small intestinal reperfusion damage. Acta Physiol Scand, 1985; 124(4)∶581.