為探討膽囊良惡性病變組織中p21、p53及bcl-2癌基因蛋白的表達及其與膽囊癌預(yù)后的關(guān)系，以及在膽囊良惡性病變的鑒別診斷中的作用，采用免疫組織化學ABC法，分別測定了40例膽囊癌及8例膽囊腺瘤型息肉組織中p21、p53及bcl2癌基因蛋白的表達情況。結(jié)果：膽囊癌組織中p21、p53及bcl-2癌基因蛋白表達陽性率分別為52.5%、52.5%和70.0%；在膽囊腺瘤型息肉中3者分別為0%、0%和100%；其中p53蛋白表達陽性率在低分化腺癌中明顯高于高分化腺癌(Ｐ＜0.01)，bcl-2蛋白表達陽性率在低分化腺癌中也明顯低于高分化腺癌(Ｐ＜0.01)。本實驗結(jié)果提示：p21及p53蛋白表達可能是膽囊癌預(yù)后不良的重要指標，檢測p21、p53及bcl-2蛋白表達情況在膽囊癌與膽囊息肉的鑒別診斷中有一定意義。
引用本文： 陳勁松,熊壽芝,楊竹林. 膽囊癌組織中p21、p53及bcl-2癌基因蛋白的表達及意義. 中國普外基礎(chǔ)與臨床雜志, 1999, 6(2): 83-85. doi: 復(fù)制
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- 2. Jansson DS, Radosevich JA, Carney WE, et al. An immunohistochemical analysis of ras oncogene expression in epithelial neoplasms of colon. Cancer, 1990; 65(2)∶1329.
- 3. Pilotl S, Collinni P, Rillke F, et al. Bcl2 protein expression in carcinomas originating from the follicular epitheliun of the tyroid gland. J Pathol, 1994; 72(1)∶337.
- 4. Masakiko Y, Takahiro F, Baisuke A, et al.Expression of oncogene products and growth factors in early gallbladder cancer, advanced gallbladder cancer and chronic cholecystitis. Hum Pathol, 1993; 24(4)∶37.
- 5. Wee A, The M, Raju GC, et al. Clinical importance of p53 protein in gallbladder carcinoma and its precursor lesions. J Clin Pathol, 1994; 47(2)∶453.
- 6. Dia K, Doglioni C, Lourinol, et al. P53 and cerb B2 protein expression in adenocarcinomas and epithelial dysplasia of the gallbladder. J Pathol, 1993; 170(4)∶67.
- 7. Rasbridge SA, Gillett CE, Symour AM, et al. The effect of che-motherapy on morpholohy, cellular proliferation aptosis and oncoprotein expression in primary breast carcinoma. Cancer, 1994; 70(1)∶335.
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