為探討胃腸外營養(yǎng)(TPN)添加精氨酸(Arg)對胃癌術(shù)后患者淋巴細胞免疫功能的影響及意義,對36例胃癌術(shù)后患者進行了TPN支持的前瞻性研究,檢測常規(guī)TPN和TPN添加Arg支持前后患者的T淋巴細胞亞群、NK細胞活性、IL-2和CD25水平變化。結(jié)果:常規(guī)TPN支持前后患者的T淋巴細胞亞群、NK細胞活性、IL-2和CD25水平變化無明顯差異,而TPN添加Arg支持后患者的CD4、CD4/CD8比值、NK細胞活性和IL-2水平均明顯增加(P<0.05)。本研究結(jié)果顯示:常規(guī)TPN不能糾正胃癌術(shù)后患者的淋巴細胞免疫功能抑制,但TPN添加Arg則可促進IL-2生成增加,NK細胞活性增強,改善了胃癌術(shù)后患者的淋巴細胞免疫功能,提示TPN添加Arg有免疫促進作用。
引用本文: 王頎,王吉甫,彭俊生. 胃腸外營養(yǎng)添加精氨酸對胃癌術(shù)后患者淋巴細胞免疫功能的作用. 中國普外基礎(chǔ)與臨床雜志, 1999, 6(2): 100-103. doi: 復制
1. | 王新江, 陸華, 谷漱燕. 用MTT比色法檢測人NK細胞活性. 中華實驗和臨床病毒學雜志, 1992; 6(1)∶69. |
2. | Daly JM, Reynolds J, Thom A, et al. Immune and metabolic effects of arginine in the surgical patient. Ann Surg, 1988; 208(4)∶512. |
3. | 曹艷英, 楊曉梅, 周正任等. 原發(fā)性肝癌病人手術(shù)前后NK活性、IL2產(chǎn)生能力、sIL2R表達水平的動態(tài)實驗研究. 中華腫瘤雜志, 1993; 5(2)∶111. |
4. | 王頎, 王吉甫, 彭俊生. 兩種脂肪乳劑對胃癌術(shù)后病人淋巴細胞免疫功能的影響. 現(xiàn)代臨床普通外科雜志, 1996; 1(3)∶150. |
5. | 張利華, 黎介壽. 全腸外營養(yǎng)及免疫調(diào)節(jié)劑對腹腔感染大鼠免疫功能的調(diào)節(jié). 中華實驗外科雜志, 1994; 11(4)∶240. |
6. | Sedman PC, Ramsden CW, Brennan TG, et al. Effects of low perioperative interferon on the surgically induced suppression of antitumour immune responses. Br J Surg, 1988; 75(9)∶976. |
7. | Madden HP, Breslin RJ, Wasserkerug HL, et al. Stimulation of cell immunity by arginine enhances survival in peritonitis. J Surg Res, 1988; 44(6)∶658. |
8. | Reynolds JV, Daly JM, Shou J, et al. Immunologic effects of arginine supplementation in tumorbearing and nontumorbearing hosts. Ann Surg, 1990; 211(2)∶202. |
9. | Liebberman MD, Nishidka K, Redmond P, et al. Enhancement of interleukin2 immunotherapy with Larginine. Ann Surg, 1992; 215(2)∶157. |
10. | Grossie VB, Nishioka K, Ajan JA, et al. Substitating ornithine for arginine in total parenteral nutrition eliminates enhanced tumor growth. J Surg Oncol, 1992; 50(2)∶161. |
11. | 王頎, 王吉甫, 彭俊生. 不同脂肪乳劑對人淋巴細胞產(chǎn)生白介素2能力和膜受體表達影響的研究. 中華實驗外科雜志, 1997; 14(增刊)∶153. |
12. | Brittenden J, Park KGM, Hayes PD, et al. Effect of arginine on natural cytotoxicity in cancer patients and healthy volunteers. Br J Surg, 1992; 79(5)∶442. |
- 1. 王新江, 陸華, 谷漱燕. 用MTT比色法檢測人NK細胞活性. 中華實驗和臨床病毒學雜志, 1992; 6(1)∶69.
- 2. Daly JM, Reynolds J, Thom A, et al. Immune and metabolic effects of arginine in the surgical patient. Ann Surg, 1988; 208(4)∶512.
- 3. 曹艷英, 楊曉梅, 周正任等. 原發(fā)性肝癌病人手術(shù)前后NK活性、IL2產(chǎn)生能力、sIL2R表達水平的動態(tài)實驗研究. 中華腫瘤雜志, 1993; 5(2)∶111.
- 4. 王頎, 王吉甫, 彭俊生. 兩種脂肪乳劑對胃癌術(shù)后病人淋巴細胞免疫功能的影響. 現(xiàn)代臨床普通外科雜志, 1996; 1(3)∶150.
- 5. 張利華, 黎介壽. 全腸外營養(yǎng)及免疫調(diào)節(jié)劑對腹腔感染大鼠免疫功能的調(diào)節(jié). 中華實驗外科雜志, 1994; 11(4)∶240.
- 6. Sedman PC, Ramsden CW, Brennan TG, et al. Effects of low perioperative interferon on the surgically induced suppression of antitumour immune responses. Br J Surg, 1988; 75(9)∶976.
- 7. Madden HP, Breslin RJ, Wasserkerug HL, et al. Stimulation of cell immunity by arginine enhances survival in peritonitis. J Surg Res, 1988; 44(6)∶658.
- 8. Reynolds JV, Daly JM, Shou J, et al. Immunologic effects of arginine supplementation in tumorbearing and nontumorbearing hosts. Ann Surg, 1990; 211(2)∶202.
- 9. Liebberman MD, Nishidka K, Redmond P, et al. Enhancement of interleukin2 immunotherapy with Larginine. Ann Surg, 1992; 215(2)∶157.
- 10. Grossie VB, Nishioka K, Ajan JA, et al. Substitating ornithine for arginine in total parenteral nutrition eliminates enhanced tumor growth. J Surg Oncol, 1992; 50(2)∶161.
- 11. 王頎, 王吉甫, 彭俊生. 不同脂肪乳劑對人淋巴細胞產(chǎn)生白介素2能力和膜受體表達影響的研究. 中華實驗外科雜志, 1997; 14(增刊)∶153.
- 12. Brittenden J, Park KGM, Hayes PD, et al. Effect of arginine on natural cytotoxicity in cancer patients and healthy volunteers. Br J Surg, 1992; 79(5)∶442.