為探討細(xì)胞間粘附分子-1(ICAM-1)和E-選擇素(E-selectin)在急性膽管炎肝微循環(huán)變化中的作用，對(duì)急性膽管炎時(shí)肝臟組織學(xué)、肝臟血流量及肝組織伊文思藍(lán)(EB)含量的變化，以及ICAM-1和E-選擇素單抗預(yù)處理對(duì)以上變化的影響進(jìn)行了觀察。結(jié)果： 急性膽管炎時(shí)肝竇內(nèi)皮細(xì)胞及肝細(xì)胞出現(xiàn)變性和結(jié)構(gòu)破壞，肝竇及肝細(xì)胞周圍多形核粒細(xì)胞(PMN)數(shù)量顯著增多，肝微血管血流量明顯減少，肝組織EB含量顯著增高，肝竇通透性增高；而抗ICAM-1及E-選擇素單抗預(yù)處理使以上損害均明顯減輕。由此表明，ICAM-1及E-選擇素在肝臟微循環(huán)障礙的發(fā)生發(fā)展中起重要作用。
引用本文： 黃顯凱,韓本立. 急性膽管炎時(shí)肝微循環(huán)的變化及其細(xì)胞間粘附分子-1和E-選擇素的作用. 中國(guó)普外基礎(chǔ)與臨床雜志, 1999, 6(5): 270-272. doi: 復(fù)制
版權(quán)信息： ?四川大學(xué)華西醫(yī)院華西期刊社《中國(guó)普外基礎(chǔ)與臨床雜志》版權(quán)所有，未經(jīng)授權(quán)不得轉(zhuǎn)載、改編
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