• 第三軍醫(yī)大學大坪醫(yī)院野戰(zhàn)外科研究所(重慶400042);

選用Wistar大鼠20只，隨機分為對照組、內(nèi)皮素-1(ET-1)組、ET-1+硝基左旋精氨酸組和ET-1+前列環(huán)素+消炎痛組，每組5只。采用氫氣清除法觀察ET-1對肝血流量的影響以及一氧化氮(NO)和前列環(huán)素(PGI2)對ET-1生物學效應(yīng)的調(diào)節(jié)作用。結(jié)果顯示：ET-1能使肝血流量迅速降低，并且持續(xù)時間較長；NO及PGI2可部分拮抗ET-1的生物學效應(yīng)。表明內(nèi)皮細胞源性血管因子對肝血流量有一定調(diào)節(jié)作用。

引用本文： 劉寶華,王代科,陳惠孫,胡德耀,楊恒文. 內(nèi)皮素對肝血流量影響的實驗研究. 中國普外基礎(chǔ)與臨床雜志, 1998, 5(4): 193-194. doi: 復(fù)制

版權(quán)信息： ?四川大學華西醫(yī)院華西期刊社《中國普外基礎(chǔ)與臨床雜志》版權(quán)所有，未經(jīng)授權(quán)不得轉(zhuǎn)載、改編

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  2. 2. 楊恒文，胡文輝，丁珍明等.大鼠脊髓腹側(cè)鼠損傷脊髓組織血流量的變化.中華神經(jīng)外科雜志， 1991； 7(2)∶87.
  3. 3. Kitsukawa Y, Gu ZF, Hildebrand P, et al. Gastric smooth muscle cells possess two classes of endothelin receptor but one alters contractin. Am J Physiol, 1994; 266(4 Pt 1)∶G713.
  4. 4. Housset C, Rockey DC, Bissell M, et al. Endothelin receptor in rat liver: lipocytes as a contractile target for endothelin1. Proc Natl Acad Sci USA, 1993; 90(10)∶9266.
  5. 5. Sakamoto M, Uero T, Kin M, et al. Ito cell contraction response to endothelin1 and substance P. Hepatology Baltimore, 1993; 18(4)∶978.
  6. 6. 劉寶華，陳惠孫.內(nèi)毒素與PGI2及NO的相互作用.國外醫(yī)學生理病理學與臨床分冊，1996； 16(1)∶46.
  7. 7. Goligorsky MS, Tsukahara H, Magazine H, et al. Termination of endothelin signaling:role of nitric oxide. J Cell Physiol, 1994; 158(5)∶485.