四氯化碳復(fù)制大鼠肝硬變模型，通過大鼠肝臟缺血再灌注損傷模型，比較硬變肝與正常肝在缺血再灌注損傷時的差異和意義。結(jié)果顯示：肝硬變時對缺血再灌注損傷反應(yīng)與正常大鼠不同，再灌注時肝臟一氧化氮合成釋放顯著增加，肝組織ATP含量明顯降低且長時間難以恢復(fù)等，可能是肝硬變時對缺血再灌注損傷更敏感、更易發(fā)生肝功能衰竭的重要原因。
引用本文： 張志成,黃志強(qiáng),孟憲鈞. 一氧化氮、血栓素/前列環(huán)素及ATP與肝硬變大鼠肝臟缺血再灌注損傷. 中國普外基礎(chǔ)與臨床雜志, 1998, 5(4): 205-207. doi: 復(fù)制
版權(quán)信息： ?四川大學(xué)華西醫(yī)院華西期刊社《中國普外基礎(chǔ)與臨床雜志》版權(quán)所有，未經(jīng)授權(quán)不得轉(zhuǎn)載、改編
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- 1. 韓德五.肝硬化動物模型研究.山西醫(yī)藥雜志， 1979； 4(1)∶1.
- 2. 王成彬，田亞平，沈文梅等.魯米諾化學(xué)發(fā)光測定一氧化氮，自由基生命科學(xué)進(jìn)展.北京：原子能出版社，1995∶159.
- 3. 李振甲，王仁芳主編.激素的放射免疫分析.第1版.北京：科學(xué)技術(shù)文獻(xiàn)出版社，1985∶138.
- 4. 嚴(yán)濤，張平，孟憲鈞等.熒光素酶系測定組織ATP、ADP、AMP水平的生物發(fā)光法.第三軍醫(yī)大學(xué)學(xué)報，1987； 9(6)∶294.
- 5. Paul CK, Rebecca AS. The emerging multifaceted role of nitric oxide. Ann Surg, 1995; 221∶220.
- 6. Askin DL, Valle MR, Heck DE, et al.Hepatic nitric oxide production following acute endotoxemia in rats is mediated by increased inducible nitric oxide synthase gene expression. Hepatology, 1995; 22(3)∶223.
- 7. Beckman JS, Beckman TW, Chen J, et al. Apparent hydroxyl radical production by reroxynitrite:implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA, 1990; 87(8)∶1620.
- 8. Billiar TR. The delicate balance of nitric oxide and superoxide in liver pathology. Gastroenterology, 1995; 108(6)∶603.
- 9. Bush LR, Campbell WB, Buja LM, et al. Effects of the selective thromboxane synthetase inhinitor dazoxiben on variatious in cyclic blood flow in stenosed canine coronary arteriess. Circulation, 1984; 69(9)∶1161.
- 10. Sikujara O, Moden M, Toyoshima K,et al. Cytoprotective effect of prostaglandin I2 on ischemiareperfusion hepatic cell injury. Transpiantantion, 1983; 36(3)∶238.
- 11. Marubayashi S, Takenaka M, Dohi K, et al. Adenine nucleotide metabolism during hepatic ischemia and subequent blood reflow periods and its relation to organ viablity. Transplantaion, 1980; 30(3)∶294.