• 1. 第一軍醫(yī)大學(xué)附屬珠江醫(yī)院普外科(廣州510282)2. 中山醫(yī)科大學(xué)附屬一院血管外科;

實(shí)驗(yàn)選用健康雜種犬21只,分為種植組(n=13),即用自體靜脈碎片種植滌綸人工血管(Dacron)間置于下腔靜脈(IVC);對(duì)照組(n=8)所用Dacron僅全血預(yù)凝。采靜脈血行血漿及血小板環(huán)磷酸腺苷(cAMP)和環(huán)磷酸鳥苷(cGMP)放免測(cè)定,并定期取移植物行形態(tài)觀察。結(jié)果:種植組移植物通暢率為61.5%,對(duì)照組為25.0%;術(shù)后2周種植組Dacron腔面形成內(nèi)皮層,對(duì)照組為血栓;種植組血漿與血小板cAMP高于對(duì)照組,cGMP低于對(duì)照組。本實(shí)驗(yàn)結(jié)果提示:自體靜脈碎片種植可促使植入犬IVC的Dacron內(nèi)皮化、血漿與血小板cAMP含量增加及cGMP含量減少,有利提高通暢率。

引用本文: 吳愛國(guó),陳國(guó)銳,楊繼震. 犬下腔靜脈重建時(shí)血小板與血漿環(huán)-磷酸腺苷及環(huán)-磷酸鳥苷的變化研究. 中國(guó)普外基礎(chǔ)與臨床雜志, 1998, 5(4): 211-213. doi: 復(fù)制

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  1. 1. 許澍淮.環(huán)核苷酸與血小板功能.生理科學(xué)進(jìn)展, 1992; 23(4)∶318.
  2. 2. Noishaki Y, Yamane Y, Tomizawa Y. Rapid endothelialization of vascular prostheses by seeding autologeous tissue fragment. J Thorac Cardiovasc Surg, 1992; 104(3)∶770.
  3. 3. 吳愛國(guó),陳國(guó)銳.自體靜脈碎片種植Dacron替代狗部分下腔靜脈的研究.中華實(shí)驗(yàn)外科雜志,1995; 12(4)∶231.
  4. 4. 章翰,李天憲,張昌菊等.單個(gè)核細(xì)胞內(nèi)cAMP提取方法的研究.中國(guó)免疫學(xué)雜志,1988; 4(1)∶42.
  5. 5. ITO RK, Rosenblatt MS, Contreras MA, et al. Monitoring platelet interaction with prosthetic graft implants in a canine model. ASAIO Trans, 1990; 36(3)∶M175.
  6. 6. 吳愛國(guó),陳國(guó)銳,楊繼震.滌綸人工血管重建犬下腔靜脈時(shí)血漿與組織6KPGF1α含量變化的研究.中國(guó)普通外科雜志,1997; 6(5)∶279.
  7. 7. Lobel P, Schror K. Stimulation of vascular prostacyclin and inhibition of platelet function by oral defibrotide in cholesterolfed rabbits. Atherosclerosis, 1989; 80(1)∶69.