為探討CD28單克隆抗體在移植免疫中的作用，以混合淋巴細(xì)胞培養(yǎng)和大鼠同種異體甲狀旁腺移植為模型，觀察mAbCD28在體外和體內(nèi)實(shí)驗(yàn)中的作用。結(jié)果：mAbCD28在體外可以抑制淋巴細(xì)胞的增殖，在體內(nèi)可以延長甲狀旁腺移植物的存活時(shí)間。本實(shí)驗(yàn)結(jié)果提示：mAbCD28可以阻斷CD28-B7之間共刺激信號(hào)的傳遞，并在同種異體大鼠甲狀旁腺移植中起到免疫抑制作用。
引用本文： 肖毅,朱預(yù),王樹蕙. mAbCD28在同種異體移植中的免疫抑制作用. 中國普外基礎(chǔ)與臨床雜志, 1998, 5(5): 260-262. doi: 復(fù)制
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- 1. Linsley PS, Ledbetter JA. The role of the CD28 receptor during T cell responses to antigen. Annu Rev Immunol, 1993; 11∶191.
- 2. 陳力真，王樹蕙，張?jiān)频?人化SCID鼠的建立及其對(duì)脊髓灰質(zhì)炎病毒的免疫應(yīng)答.中華微生物學(xué)和免疫學(xué)雜志，1995； 15∶82.
- 3. Martin PJ, Ledbetter JA, Morishita Y, et al. A 44 kilodalton cell surface homodimer regulates interleukin 2 production by activated human T lymphocytes. J Immunol, 1986; 136∶3282.
- 4. Damle NK, Doyle LV, Grosmaire LS, et al. Differential regulatory signals delivered by antibody binding to the CD28 (Tp44) molecule during the activation of human T lymphocytes. J Immunol, 1988; 140∶1753.
- 5. Lin H, Bolling SF, Linsley PS, et al. Longterm acceptance of major histocompatbility complex mismatched cardiac allografts induced by CTLA4 Ig plus donorspecific transfusion. J Exp Med, 1993; 178∶1801.