• 1.廣州市第一人民醫(yī)院普外科(廣州510180);;
  • 2.廣州市第一人民醫(yī)院病理科;;
  • 3.廣州市第一人民醫(yī)院內(nèi)科;;
  • 4.北京醫(yī)科大學(xué)分析計算中心;

采用自動化圖像分析技術(shù)對47例殘胃黏膜異型增生細胞核進行DNA含量測定，并與15例無異型增生和10例殘胃癌標本進行比較。結(jié)果顯示：其DNA含量及細胞核面、周長、最大徑和最小徑均隨異型增生程度的加重呈遞增改變(P lt;0.01)，而形狀因子則呈遞減改變(P lt;0.05)；DNA含量直方圖呈規(guī)律性改變，特別是重度異型增生與殘胃癌在生物學(xué)特性方面具相似性。因此，測定細胞核DNA含量可為殘胃黏膜異型增生的分級、隨訪及癌變預(yù)測提供客觀依據(jù)。

引用本文： 曹杰 ,杜洪,曾軍,譚衛(wèi)民,何其華. 殘胃黏膜異型增生細胞核DNA含量分析及臨床意義. 中國普外基礎(chǔ)與臨床雜志, 1997, 4(1): 13-16. doi: 復(fù)制

版權(quán)信息： ?四川大學(xué)華西醫(yī)院華西期刊社《中國普外基礎(chǔ)與臨床雜志》版權(quán)所有，未經(jīng)授權(quán)不得轉(zhuǎn)載、改編

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  1. 1. Vogt T,Stolz W,Braun-Falco O,et al.Prognostic significance of DNA cytometry in cutaneous malignant lymphomas.Cancer,1991;68:1095.
  2. 2. Tosi P,Luzi P,Baak JPA,et al.Gastric dysplasia:a stereological and morphometrical assessment.J Pathol,1987;152:83.
  3. 3. Ming S,Bajtai A,Correa P,et al.Gastric dysplasia:significance and pathologic criteria.Cancer,1984;54:1794.
  4. 4. Corral M,Pardo-Mindan F,Razquin S,et al.Risk of cancer in patients with gastric dysplasia:follow-up study of 67 patients.Cancer,1990;65:2078.
  5. 5. Tytgat G,Offerhaus J,Stadt J,et al.Early gastric stump cancer:macroscopic and microscopic appearance.Hepatogastroenterol,1989,36:103.
  6. 6. Farinati F,Cardin F,Mario F,et al.Follow-up in gastric dysplasia patients.Am J Surg Pathol,1989;13:173.
  7. 7. Morson BC,Sobin L,Grundmann E,et al.Precancerous condition and epithelial dysplasia in the stomach.J Clin Pathol,1980;33:711.
  8. 8. Baba H,Korenaga D,OKamura T,et al.Comparison of DNA content in gastric cancer cells between primary lesions and lymph node metastases.Cancer,1990;66:1775.
  9. 9. 曹 杰,劉錦懷.圖像法DNA定量分析在胃腸腫瘤臨床中的應(yīng)用前景.《國外醫(yī)學(xué)》生理、病理科學(xué)與臨床分冊,1994;14:48.
  10. 10. Green F,Gastroscopic screening of the postgastrectomy stomach:relationship of dysplasia to remnant cancer.Am Surg,1989;55:12.