19只貓隨機分成A組和B組。A組7只接受全胰腺點狀注射酒精，B組12只經(jīng)主胰管插管注射酒精，并將導管留在主胰管內造成主胰管部分梗阻，再全胰腺點狀注射酒精。結果：術后全部實驗貓均發(fā)生急性壞死性胰腺炎（ANP）。A組2只貓（28.6%）在48小時內死亡，5只貓術后6周胰腺組織形態(tài)和外分泌功能基本恢復正常。B組死亡4只（占33.3%），其中3只在術后48小時內死亡，另1只在術后2周死亡。其余8只貓術后15周全部發(fā)展成慢性胰腺炎。由此提示單純胰腺壞死可在致病因去除后得到恢復；如果致病因繼續(xù)起作用，可造成組織學和功能方面的不可逆損害，最終可能發(fā)展成慢性胰腺炎。
引用本文： 趙華,屠建,鐘守先,唐偉松. 貓胰腺壞死后的轉歸初探. 中國普外基礎與臨床雜志, 1996, 3(1): 1-3. doi: 復制
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- 1. Ehrhardt-Schmelzer S,Otto J,Schlaeger R,et al.Fecal chymotrypsin for investigation of exocrine pancreatic function:a comparison of two newly developed tests with the titrimeteric method.Gastroenterol,1984;22:647.
- 2. Lankisch PG,Brauneis J,Otto J,et al.Pancreolauryl and NBT-PABA tests.Gastroenterol,1986;90:350.
- 3. Van De Kamer JH,Ten Bokkel Huinink H,Weyers HA.Rapid method for the determination of fat in the feces.J Biol Chem,1949;177:347.
- 4. Beger HG.Surgical management of necrotizing pancreatitis.Surg Clin North Am,1989;69:529.
- 5. Bradley EL Ⅲ,Allen K.A prospective longitudinal study of observation versus surgical intervention in the management of necrotizing pancreatitis.Am J Surg,1991;161:l0.
- 6. Warshaw AL.A guide to pancreatitis.Comp Ther,l980;6:49.
- 7. Fenton-Lee D,Imrie CW.Pancreatic necrosis:assessment of outcome related to quality of life and cost of management.Br J Surg,1993;80(12):1579.
- 8. Mitchell CJ,Playforth MJ,Mcmahon MJ.Functional recovery of the exocrine pancreas after acutepancreatitis.Scand J Gastroenterol,1983;18:5.
- 9. Sarles H.Proposal adopted unanimously by thepartocipants of the symposium on pancreatitis at marseilles.Gastroentecol,1965;7:7.
- 10. Klopple G,Maillet B.The morphological basis for the evolution of acute pancreatitis into chronic pancreatitis.Virchows Archiv A Pothol Anat,l992;420:1.