• 1.第三軍醫(yī)大學附屬大坪醫(yī)院普外科（重慶630042）2.解放軍60醫(yī)院外科;

檢測43例大腸癌患者血清、癌組織及癌旁粘膜中生長抑素水平。結果大腸癌患者術前空腹血清生長抑素含量明顯低于對照組（P lt;0.001），根治術后明顯高于術前（P lt;0.01），但仍明顯低于對照組（P lt;0.001）。大腸癌組織中生長抑素含量明顯低于正常大腸粘膜（P lt;0.001），亦低于癌旁粘膜（P lt;0.001），但血清及癌組織中生長抑素水平與大腸癌組織學類型及Duke’s分期均無顯著關系。提示生長抑素對大腸癌的生長具有負調(diào)控作用，從而為大腸癌患者應用生長抑素類藥物治療提供實驗依據(jù)。

引用本文： 何雙梧,李家琪,李義兵,謝尚奎. 大腸癌患者血清及癌組織中生長抑素水平測定的臨床意義. 中國普外基礎與臨床雜志, 1996, 3(4): 208-210. doi: 復制

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  1. 1. Smith JP,Solomom TE.Effects of gastrin proglumide and somatostatin on growth of human colon cancer.Gastroenterology,1988;95:1941.
  2. 2. 劉文忠,江紹基,肖樹東.胃腸激素和消化系腫瘤.基礎醫(yī)學與臨床,1992;12:12.
  3. 3. Miller GV,Farmery SM,Woodhouse LF,et al.Somatostatin binding in normal and malignant human gastrointestinal mucosa.Br J Cancer,1992;66:391.
  4. 4. Damage CS,Hairi A,Karsenty L,et al.Somatostatin action in tumor models.Metabalism,1992;41:11.
  5. 5. Radulovic S,Schally AV,Reile H,et al.Inhibitory effects of antagonisis of bombesin/gastrin releasing peptide and somatostatin analog(RC-160)on growth of HT-29 human colon cancers in nude mice.Acta Oncol,1994;33:693.
  6. 6. Itzeu BD,Lolova I,Davidoff M.Immunocytochemical and electromicroscopical data on the differentiation of somatostatin-cantaining cells in human large intestine.Anat Anz Jena,1988;166:77.