作者采用上皮細(xì)胞膜抗原單克隆抗體(EMA)免疫組化ABC法對(duì)65例胃癌患者有無(wú)骨髓微小轉(zhuǎn)移灶進(jìn)行定量檢測(cè)。結(jié)果:從38例患者骨髓中發(fā)現(xiàn)了陽(yáng)性細(xì)胞,陽(yáng)性細(xì)胞檢出率為58.46%(38/65),而且該38例陽(yáng)性患者綜合治療前后陽(yáng)性結(jié)果有顯著變化(t=2.77 P<0.005)。由此表明,此項(xiàng)技術(shù)不但能早期確定胃癌有無(wú)血行和骨髓轉(zhuǎn)移,而且對(duì)指導(dǎo)臨床綜合治療也有重要的意義。
引用本文: 趙增順,黎介壽,劉福坤,譚海東,曹曉穎,藏靜,王少文. 單克隆抗體對(duì)胃癌患者骨髓微小轉(zhuǎn)移的定量檢測(cè)及其臨床意義. 中國(guó)普外基礎(chǔ)與臨床雜志, 1995, 2(2): 68-70. doi: 復(fù)制
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- 1. Dearnalery J, ormerod N. In creaed detection no mamary carcinoma cells marrow smers using antigen to apithelial membrance antigen. Br J Cancer,1981;44(1):85.
- 2. Rivhardson J, Pulford K. Production of monoclonal antibody against human spithelial membrane antigen for use in diagnostic immunochemistry. Br J Cancer,1985;52(2):347.
- 3. 趙增順,劉福坤,黎介壽等.抗膜上皮抗原單克隆抗體對(duì)胃癌患者骨髓微小轉(zhuǎn)移的臨床研究.中華腫瘤雜志,1994;16(4):283.
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