• 1 福建醫(yī)科大學(xué)省立臨床學(xué)院 福建省立醫(yī)院呼吸內(nèi)科（福建福州 350001）;;
  • 2 福建醫(yī)科大學(xué);;
  • 3 福建省心血管病重點(diǎn)實(shí)驗(yàn)室;

目的  探討社區(qū)獲得性肺炎(CAP)患者可溶性細(xì)胞間黏附分子1（sICAM-1）和可溶性血管細(xì)胞黏附分子1（sVCAM-1）水平的變化及意義。方法   使用酶聯(lián)免疫吸附（ELISA）雙抗體夾心法動(dòng)態(tài)檢測(cè)25例CAP患者治療前后情況及10例健康對(duì)照組血清sICAM-1、sVCAM-1的水平。結(jié)果  CAP組患者治療前sICAM-1和sVCAM-1分別為(2.658 4±0.259 7)ng/mL、（2.680 9±0.255 4)ng/mL，對(duì)照組的sICAM-1和sVCAM-1分別為(2.472 8±0.077 6)ng/mL、（2.426 3±0.307 2)ng/mL，兩組比較差異均有統(tǒng)計(jì)學(xué)意義(P lt;0．01,P lt;0．05)。CAP組患者治療后sICAM-1和sVCAM-1分別為(2.518 3±0.205 2)ng/mL、（2.523 0±0.279 4)ng/mL，與治療前比較明顯下降，差異有統(tǒng)計(jì)學(xué)意義(P均 lt;0．01)；而與對(duì)照組比較差異無統(tǒng)計(jì)學(xué)意義（P均 gt;0.05）。sICAM-1水平表達(dá)與中性粒細(xì)胞計(jì)數(shù)呈正相關(guān)（r=0.602，P lt;0.001）；sVCAM-1水平與中性粒細(xì)胞計(jì)數(shù)無明顯相關(guān)性（r＝0.036，P gt;0.05）。結(jié)論  社區(qū)獲得性肺炎患者sICAM-1和sVCAM-1水平隨肺炎治療顯效后下降，動(dòng)態(tài)檢測(cè)血清sICAM-1及sVCAM-1水平有助于判斷肺炎病情的轉(zhuǎn)歸。

引用本文： 陳愉生 ,謝寶松,林明,許能鑾,林章樹,李瑞慧,李鴻茹,林立芳. 社區(qū)獲得性肺炎患者血清可溶性細(xì)胞間黏附分子1和可溶性血管細(xì)胞黏附分子1的變化及意義. 中國呼吸與危重監(jiān)護(hù)雜志, 2008, 08(1): 26-29. doi: 復(fù)制

1. Demir T，Yalçinoz C，Keskinel I，et al.sICAM-1 as a serum marker in the diagnosis and follow-up of treatment of pulmonary tuberculosis.Int J Tuberc Lung Dis，2002，6：155-159.
2. Hansen AB，Verder H，Staun-Olsen P.Soluble intercellular adhesion molecule and C-reactive protein as early markers of infection in newborns.J Perinat Med，2000，28：97-103.
3. Koizumi A，Hashimoto S，Kobayashi T，et al.Elevation of serum soluble vascular cell adhesion molecule-1 (sVCAM-1) levels in bronchial asthma.Clin Exp Immunol，1995，101：468-473.
4. 陳曉東，王順賓，江瓊，等.嚴(yán)重?zé)齻颊哐錽ICAM-1和sVCAM-1水平的變化及與感染的關(guān)系.中國急救醫(yī)學(xué)，2004，24：109-111.
5. Südhoff T，Wehmeier A，Arning M，et al.Increases of sICAM-1 during neutropenic pneumonia in leukemic patients.Leukemia，1997，11：346-351.
6. Glynn P，Coakley R，Kilgallen I，et al.NeutroPhil CD11b and soluble ICAM-1 and E-selectin in community acquired Pneumonia.Eur Respir J，1999，13：1380-1385.
7. 葉璟，何時(shí)軍，嚴(yán)純雪，等.肺炎患兒血清可溶性細(xì)胞間黏附分子-1的變化及意義.實(shí)用醫(yī)學(xué)雜志，2005，21：1150-1151.
8. Kobayashi T，Hashimoto S，Imai K，et al.Elevation of serum soluble intercellular adhesion molecule-1 (sICAM-1) and sE-selectin levels in bronchial asthma.Clin Exp Immunol，1994，96：110-115.
9. Zhou Z，Liu Y，Miao AD，et al.Protocatechuic aldehyde suppresses TNF-alpha-induced ICAM-1 and VCAM-1 expression in human umbilical vein endothelial cells.Eur J Pharmacol，2005，513：1-8.
10. Hayashi T，Hasegawa K，Ichinohe N，et al.ICAM-1 expression on endothelium and systemic cytokine production in cutaneous neutrophilic leukocytoclastic vasculitis in NZBxNZWF1 mice.Histol Histopathol，2005，20：45-52.
11. Yang L，F(xiàn)roio RM，Sciuto TE，et al.ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-alpha-activated vascular endothelium under flow.Blood，2005，106：584-592.
12. Murata K，Takayanagi T，Mano Y，et al.Serum levels of soluble adhesion molecules in patients with inflammatory myopathi.Rinsho Shinkeigaku，1996，36：12-16.
13. 宋金枝，文飛球，周克英，等.新生兒細(xì)菌感染血淋巴細(xì)胞ICAM-1和L-selectin的變化及意義.中國感染控制雜志，2004，3：208-210.
14. Spark JI，Scott DJ，Chetter IC，et al.Does soluble intercellular adhesion molecule-1 (ICAM-1) affect neutrophil activation and adhesion following ischaemia-reperfusion? Eur J Vasc Endovasc Surg，1999，17：115-120.
15. Harlan JM，Winn RK.Leukocyte-endothelial interactions：clinical trials of anti-adhesion therapy.Crit Care Med，2002，30：S214-S219.
  1. 1. Demir T，Yalçinoz C，Keskinel I，et al.sICAM-1 as a serum marker in the diagnosis and follow-up of treatment of pulmonary tuberculosis.Int J Tuberc Lung Dis，2002，6：155-159.
  2. 2. Hansen AB，Verder H，Staun-Olsen P.Soluble intercellular adhesion molecule and C-reactive protein as early markers of infection in newborns.J Perinat Med，2000，28：97-103.
  3. 3. Koizumi A，Hashimoto S，Kobayashi T，et al.Elevation of serum soluble vascular cell adhesion molecule-1 (sVCAM-1) levels in bronchial asthma.Clin Exp Immunol，1995，101：468-473.
  4. 4. 陳曉東，王順賓，江瓊，等.嚴(yán)重?zé)齻颊哐錽ICAM-1和sVCAM-1水平的變化及與感染的關(guān)系.中國急救醫(yī)學(xué)，2004，24：109-111.
  5. 5. Südhoff T，Wehmeier A，Arning M，et al.Increases of sICAM-1 during neutropenic pneumonia in leukemic patients.Leukemia，1997，11：346-351.
  6. 6. Glynn P，Coakley R，Kilgallen I，et al.NeutroPhil CD11b and soluble ICAM-1 and E-selectin in community acquired Pneumonia.Eur Respir J，1999，13：1380-1385.
  7. 7. 葉璟，何時(shí)軍，嚴(yán)純雪，等.肺炎患兒血清可溶性細(xì)胞間黏附分子-1的變化及意義.實(shí)用醫(yī)學(xué)雜志，2005，21：1150-1151.
  8. 8. Kobayashi T，Hashimoto S，Imai K，et al.Elevation of serum soluble intercellular adhesion molecule-1 (sICAM-1) and sE-selectin levels in bronchial asthma.Clin Exp Immunol，1994，96：110-115.
  9. 9. Zhou Z，Liu Y，Miao AD，et al.Protocatechuic aldehyde suppresses TNF-alpha-induced ICAM-1 and VCAM-1 expression in human umbilical vein endothelial cells.Eur J Pharmacol，2005，513：1-8.
  10. 10. Hayashi T，Hasegawa K，Ichinohe N，et al.ICAM-1 expression on endothelium and systemic cytokine production in cutaneous neutrophilic leukocytoclastic vasculitis in NZBxNZWF1 mice.Histol Histopathol，2005，20：45-52.
  11. 11. Yang L，F(xiàn)roio RM，Sciuto TE，et al.ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-alpha-activated vascular endothelium under flow.Blood，2005，106：584-592.
  12. 12. Murata K，Takayanagi T，Mano Y，et al.Serum levels of soluble adhesion molecules in patients with inflammatory myopathi.Rinsho Shinkeigaku，1996，36：12-16.
  13. 13. 宋金枝，文飛球，周克英，等.新生兒細(xì)菌感染血淋巴細(xì)胞ICAM-1和L-selectin的變化及意義.中國感染控制雜志，2004，3：208-210.
  14. 14. Spark JI，Scott DJ，Chetter IC，et al.Does soluble intercellular adhesion molecule-1 (ICAM-1) affect neutrophil activation and adhesion following ischaemia-reperfusion? Eur J Vasc Endovasc Surg，1999，17：115-120.
  15. 15. Harlan JM，Winn RK.Leukocyte-endothelial interactions：clinical trials of anti-adhesion therapy.Crit Care Med，2002，30：S214-S219.

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