目的 探討社區(qū)獲得性肺炎(CAP)患者可溶性細(xì)胞間黏附分子1(sICAM-1)和可溶性血管細(xì)胞黏附分子1(sVCAM-1)水平的變化及意義。方法 使用酶聯(lián)免疫吸附(ELISA)雙抗體夾心法動(dòng)態(tài)檢測(cè)25例CAP患者治療前后情況及10例健康對(duì)照組血清sICAM-1、sVCAM-1的水平。結(jié)果 CAP組患者治療前sICAM-1和sVCAM-1分別為(2.658 4±0.259 7)ng/mL、(2.680 9±0.255 4)ng/mL,對(duì)照組的sICAM-1和sVCAM-1分別為(2.472 8±0.077 6)ng/mL、(2.426 3±0.307 2)ng/mL,兩組比較差異均有統(tǒng)計(jì)學(xué)意義(P lt;0.01,P lt;0.05)。CAP組患者治療后sICAM-1和sVCAM-1分別為(2.518 3±0.205 2)ng/mL、(2.523 0±0.279 4)ng/mL,與治療前比較明顯下降,差異有統(tǒng)計(jì)學(xué)意義(P均 lt;0.01);而與對(duì)照組比較差異無統(tǒng)計(jì)學(xué)意義(P均 gt;0.05)。sICAM-1水平表達(dá)與中性粒細(xì)胞計(jì)數(shù)呈正相關(guān)(r=0.602,P lt;0.001);sVCAM-1水平與中性粒細(xì)胞計(jì)數(shù)無明顯相關(guān)性(r=0.036,P gt;0.05)。結(jié)論 社區(qū)獲得性肺炎患者sICAM-1和sVCAM-1水平隨肺炎治療顯效后下降,動(dòng)態(tài)檢測(cè)血清sICAM-1及sVCAM-1水平有助于判斷肺炎病情的轉(zhuǎn)歸。
引用本文: 陳愉生 ,謝寶松,林明,許能鑾,林章樹,李瑞慧,李鴻茹,林立芳. 社區(qū)獲得性肺炎患者血清可溶性細(xì)胞間黏附分子1和可溶性血管細(xì)胞黏附分子1的變化及意義. 中國呼吸與危重監(jiān)護(hù)雜志, 2008, 08(1): 26-29. doi: 復(fù)制
1. | Demir T,Yalçinoz C,Keskinel I,et al.sICAM-1 as a serum marker in the diagnosis and follow-up of treatment of pulmonary tuberculosis.Int J Tuberc Lung Dis,2002,6:155-159. |
2. | Hansen AB,Verder H,Staun-Olsen P.Soluble intercellular adhesion molecule and C-reactive protein as early markers of infection in newborns.J Perinat Med,2000,28:97-103. |
3. | Koizumi A,Hashimoto S,Kobayashi T,et al.Elevation of serum soluble vascular cell adhesion molecule-1 (sVCAM-1) levels in bronchial asthma.Clin Exp Immunol,1995,101:468-473. |
4. | 陳曉東,王順賓,江瓊,等.嚴(yán)重?zé)齻颊哐錽ICAM-1和sVCAM-1水平的變化及與感染的關(guān)系.中國急救醫(yī)學(xué),2004,24:109-111. |
5. | Südhoff T,Wehmeier A,Arning M,et al.Increases of sICAM-1 during neutropenic pneumonia in leukemic patients.Leukemia,1997,11:346-351. |
6. | Glynn P,Coakley R,Kilgallen I,et al.NeutroPhil CD11b and soluble ICAM-1 and E-selectin in community acquired Pneumonia.Eur Respir J,1999,13:1380-1385. |
7. | 葉璟,何時(shí)軍,嚴(yán)純雪,等.肺炎患兒血清可溶性細(xì)胞間黏附分子-1的變化及意義.實(shí)用醫(yī)學(xué)雜志,2005,21:1150-1151. |
8. | Kobayashi T,Hashimoto S,Imai K,et al.Elevation of serum soluble intercellular adhesion molecule-1 (sICAM-1) and sE-selectin levels in bronchial asthma.Clin Exp Immunol,1994,96:110-115. |
9. | Zhou Z,Liu Y,Miao AD,et al.Protocatechuic aldehyde suppresses TNF-alpha-induced ICAM-1 and VCAM-1 expression in human umbilical vein endothelial cells.Eur J Pharmacol,2005,513:1-8. |
10. | Hayashi T,Hasegawa K,Ichinohe N,et al.ICAM-1 expression on endothelium and systemic cytokine production in cutaneous neutrophilic leukocytoclastic vasculitis in NZBxNZWF1 mice.Histol Histopathol,2005,20:45-52. |
11. | Yang L,F(xiàn)roio RM,Sciuto TE,et al.ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-alpha-activated vascular endothelium under flow.Blood,2005,106:584-592. |
12. | Murata K,Takayanagi T,Mano Y,et al.Serum levels of soluble adhesion molecules in patients with inflammatory myopathi.Rinsho Shinkeigaku,1996,36:12-16. |
13. | 宋金枝,文飛球,周克英,等.新生兒細(xì)菌感染血淋巴細(xì)胞ICAM-1和L-selectin的變化及意義.中國感染控制雜志,2004,3:208-210. |
14. | Spark JI,Scott DJ,Chetter IC,et al.Does soluble intercellular adhesion molecule-1 (ICAM-1) affect neutrophil activation and adhesion following ischaemia-reperfusion? Eur J Vasc Endovasc Surg,1999,17:115-120. |
15. | Harlan JM,Winn RK.Leukocyte-endothelial interactions:clinical trials of anti-adhesion therapy.Crit Care Med,2002,30:S214-S219. |
- 1. Demir T,Yalçinoz C,Keskinel I,et al.sICAM-1 as a serum marker in the diagnosis and follow-up of treatment of pulmonary tuberculosis.Int J Tuberc Lung Dis,2002,6:155-159.
- 2. Hansen AB,Verder H,Staun-Olsen P.Soluble intercellular adhesion molecule and C-reactive protein as early markers of infection in newborns.J Perinat Med,2000,28:97-103.
- 3. Koizumi A,Hashimoto S,Kobayashi T,et al.Elevation of serum soluble vascular cell adhesion molecule-1 (sVCAM-1) levels in bronchial asthma.Clin Exp Immunol,1995,101:468-473.
- 4. 陳曉東,王順賓,江瓊,等.嚴(yán)重?zé)齻颊哐錽ICAM-1和sVCAM-1水平的變化及與感染的關(guān)系.中國急救醫(yī)學(xué),2004,24:109-111.
- 5. Südhoff T,Wehmeier A,Arning M,et al.Increases of sICAM-1 during neutropenic pneumonia in leukemic patients.Leukemia,1997,11:346-351.
- 6. Glynn P,Coakley R,Kilgallen I,et al.NeutroPhil CD11b and soluble ICAM-1 and E-selectin in community acquired Pneumonia.Eur Respir J,1999,13:1380-1385.
- 7. 葉璟,何時(shí)軍,嚴(yán)純雪,等.肺炎患兒血清可溶性細(xì)胞間黏附分子-1的變化及意義.實(shí)用醫(yī)學(xué)雜志,2005,21:1150-1151.
- 8. Kobayashi T,Hashimoto S,Imai K,et al.Elevation of serum soluble intercellular adhesion molecule-1 (sICAM-1) and sE-selectin levels in bronchial asthma.Clin Exp Immunol,1994,96:110-115.
- 9. Zhou Z,Liu Y,Miao AD,et al.Protocatechuic aldehyde suppresses TNF-alpha-induced ICAM-1 and VCAM-1 expression in human umbilical vein endothelial cells.Eur J Pharmacol,2005,513:1-8.
- 10. Hayashi T,Hasegawa K,Ichinohe N,et al.ICAM-1 expression on endothelium and systemic cytokine production in cutaneous neutrophilic leukocytoclastic vasculitis in NZBxNZWF1 mice.Histol Histopathol,2005,20:45-52.
- 11. Yang L,F(xiàn)roio RM,Sciuto TE,et al.ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-alpha-activated vascular endothelium under flow.Blood,2005,106:584-592.
- 12. Murata K,Takayanagi T,Mano Y,et al.Serum levels of soluble adhesion molecules in patients with inflammatory myopathi.Rinsho Shinkeigaku,1996,36:12-16.
- 13. 宋金枝,文飛球,周克英,等.新生兒細(xì)菌感染血淋巴細(xì)胞ICAM-1和L-selectin的變化及意義.中國感染控制雜志,2004,3:208-210.
- 14. Spark JI,Scott DJ,Chetter IC,et al.Does soluble intercellular adhesion molecule-1 (ICAM-1) affect neutrophil activation and adhesion following ischaemia-reperfusion? Eur J Vasc Endovasc Surg,1999,17:115-120.
- 15. Harlan JM,Winn RK.Leukocyte-endothelial interactions:clinical trials of anti-adhesion therapy.Crit Care Med,2002,30:S214-S219.