目的 探討骨化性氣管支氣管病( TO) 的臨床特點(diǎn)、診斷及治療。方法 報(bào)告2 例TO患者的臨床資料, 結(jié)合文獻(xiàn)分析。結(jié)果 TO 在成年人多發(fā), 男性發(fā)病率略高, 臨床癥狀無(wú)特異性。纖維支氣管鏡是診斷TO 的金標(biāo)準(zhǔn), 鏡下可見(jiàn)大氣道前壁和側(cè)壁多發(fā)增生性結(jié)節(jié)突向管腔, 后壁( 膜部)通常不受累。胸部CT 的敏感性和特異性均很高, 在TO的診斷中起重要作用。組織病理活檢可見(jiàn)支氣管黏膜下軟骨和骨組織的存在。目前尚無(wú)針對(duì)TO 的特異性治療方法, 僅少數(shù)導(dǎo)致氣道重度狹窄的患者需接受手術(shù)治療。結(jié)論 TO 是一種良性疾病, 預(yù)后較好, 肺部CT、纖維支氣管鏡有特征性改變, 可以確診。
引用本文： 葉俊,譚曉明,石昭泉,修清玉,夏春燕. 骨化性氣管支氣管病二例報(bào)道并文獻(xiàn)復(fù)習(xí). 中國(guó)呼吸與危重監(jiān)護(hù)雜志, 2010, 9(1): 66-69. doi: 復(fù)制
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- 1. 陳建英,張心范,劉濤.骨化性氣管支氣管病誤診為支氣管內(nèi)膜結(jié)核.臨床誤診誤治,2002,15:177.
- 2. 羅紅,周銳,鄭東元.骨化性氣管支氣管病4例分析.中國(guó)現(xiàn)代醫(yī)學(xué)雜志,2003,13:107-108.
- 3. 王珊娟,張馬忠,杭燕南,等.彌漫性氣管骨化一例.中華麻醉學(xué)雜志,2004,24:104.
- 4. 李海峰,鄧毅書(shū),冷靜.骨化性氣管支氣管病1例報(bào)告.中華醫(yī)學(xué)全科雜志,2004,3:46-48.
- 5. 金旭如,陳成水,李玉萍,等.骨化性氣管支氣管病3例臨床分析.浙江醫(yī)學(xué),2005,27:223-225.
- 6. 龔建化,馬經(jīng)平,張家洪,等.骨化性氣管支氣管病1例報(bào)告.中國(guó)醫(yī)師進(jìn)修雜志-內(nèi)科版,2006,29:73.
- 7. 張偉,趙怡卓,韓寶惠,等.骨化性氣管支氣管病二例報(bào)道及文獻(xiàn)復(fù)習(xí).上海醫(yī)學(xué),2006,29:772-774.
- 8. 王龐,項(xiàng)軼,高蓓莉,等.骨化性氣管支氣管病1例.診斷學(xué):理論與實(shí)踐,2007,6:61-62.
- 9. 王慧紅,林云,馮加喜,等.骨化性氣管支氣管病1例.實(shí)用醫(yī)學(xué)雜志,2007,23:3298.
- 10. 李慧梅,劉怡芝.骨化性氣管支氣管病1例及文獻(xiàn)復(fù)習(xí).中國(guó)醫(yī)師進(jìn)修雜志,2007,30（10）:74-75.
- 11. 徐虹,李偉峰,黃文杰.骨化性氣管支氣管病1例.廣東醫(yī)學(xué),2008,29:398.
- 12. Matsuba T, Komori M, Matsunaga R,et al. A case of tracheobronchopathia osteochondroplastica diagnosed by fiberoptic bronchoscopy upon removal of an aspirated crown. Diagn Ther Endosc.2001,7:63-67.
- 13. Leske V, Lazor R, Coetmeur D,et al.Tracheobronchopathia osteochondroplastica: a study of 41 patients.Medicine (Baltimore),2001,80:378-390.
- 14. Hussain K, Gilbert S.Tracheopathia osteochondroplastica.Clin Med Res,2003,1:239-242.
- 15. Barthwal MS, Chatterji RS, Mehta A.Tracheobronchopathia osteochondroplastica.Indian J Chest Dis Allied Sci,2004,46:43-46..
- 16. Kart L, Kiraz K, Büyüko?lan H, et al .Tracheobronchopathia osteochondroplastica: two cases and review of literature.Tuberk Toraks,2004,52:268-271.
- 17. Simsek PO,Ozcelik U,Demirkazik F,et al.Tracheobronchopathia osteochondroplastica in a 9-year-old girl.Pediatr Pulmonol,2006,41:95-97.
- 18. Tadjeddein A,Khorgami Z,Akhlaghi H.Tracheobronchopathia osteoplastica: cause of difficult tracheal intubation.Ann Thorac Surg,2006,81:1480-1482.
- 19. Willms H,Wiechmann V,Sack U,et al.Tracheobronchopathia osteochondroplastica: A rare cause of chronic cough with haemoptysis.Cough,2008,4:4.
- 20. Jabbardarjani HR, Radpey B, Kharabian S, et al.Tracheobronchopathia osteochondroplastica: presentation of ten cases and review of the literature.Lung,2008,186:293-297.
- 21. Moura E Sa J, Almeida J, Amado J, et al.Tracheobronchopathia osteochondroplastica Experience of a Bronchology Unit.Rev Port Pneumol,2003,4:329-40.
- 22. Tajima K,Yamakawa M,Katagiri T,et al.Immunohistochemical detection of bone morphogenetic protein-2 and transforming growth factor beta-1 in tracheopathia osteochondroplastica.Virchows Arch,1997,431:359-363.
- 23. Abu-Hijleh M, Lee D, Braman SS.Tracheobronchopathia osteochondroplastica: a rare large airway disorder.Lung,2008,186:353-359.