• 四川大學(xué)華西醫(yī)院腎臟內(nèi)科（成都，610041）;

目的 　探討抗核抗體（ANA）在IgA腎病中的陽(yáng)性率及其對(duì)臨床的意義。 方法 　回顧性分析2007年1月－2009年12月間進(jìn)行ANA檢測(cè)的115例IgA腎病患者及59例非IgA腎病慢性腎炎患者的臨床資料。統(tǒng)計(jì)分析ANA陽(yáng)性與陰性的臨床指標(biāo)。 結(jié)果 　IgA腎病患者中有12例（10.4%）存在ANA陽(yáng)性，與非IgA腎病慢性腎炎中的陽(yáng)性率比較差異無(wú)統(tǒng)計(jì)學(xué)意義（P＞0.05），ANA陽(yáng)性的IgA腎病血漿IgG水平較高，病理改變較輕。 結(jié)論 　IgA腎病ANA陽(yáng)性的機(jī)體免疫有增強(qiáng)，腎功、尿蛋白及病理?yè)p害較輕，其對(duì)IgA腎病預(yù)后的影響仍需進(jìn)一步研究。

引用本文： 張紫媛,楊滿,李青,蔣易容,文集,樊均明. IgA腎病抗核抗體陽(yáng)性的臨床意義. 華西醫(yī)學(xué), 2012, 27(3): 325-328. doi: 復(fù)制

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2. 　Lee SM, Rao VM, Franklin WA, et al. IgA nephropathy: morphologic predictors of progressive renal disease[J]. Hum Pathol, 1982, 13(4): 314-322.
3. 　肖俊, 朱玲燕, 陳崴, 等. 調(diào)節(jié)性及輔助性T細(xì)胞在人類IgA腎病中的表達(dá)及意義[J]. 中華腎臟病雜志, 2008, 24(8): 544-549.
4. 　Layward L, Allen AC, Hattersley JM, et al. Elevation of IgA in IgA nephropathy is localized in the serum and not saliva and is restricted to the IgA1 subclass[J]. Nephrol Dial Transplant, 1993, 8(1): 25-28.
5. 　Suzuki H, Fan R, Zhang Z, et al. Aberrantly glycosylated IgA1 in IgA nephropathy patients is recognized by IgG antibodies with restricted heterogeneity[J]. J Clin Invest, 2009, 119(6): 1668-1677.
6. 　Leusehner U. Primary biliary cirrhesis-presentation and diagnosis[J]. Clin Liver Dis, 2003, 7(4): 741-758.
7. 　Suzuki H, Moldoveanu Z, Hall S, et al. IgA1-secreting cell lines from patients with IgA nephropathy produce aberrantly glycosylated IgA1[J]. J Clin Invest, 2008, 118(2): 629-639.
8. 　Hazzan R, Mukamel M,Yacobovich J, et al. Risk factors for future development ofsystemic lupus erythematosus in children with idiopathic thrombocytopenic purpura[J]. Pediatr Blood Cancer, 2006, 47(5 Suppl): 657-659.
9. 　Irie F, Kobayashi M, Hirayama K, et al. Rheumatoid arthritis associated with membranous nephropathy and lgA nephritis with necrotizing lesions[J]. Nephrol Dial Transplant, 1996, 11(7): 1338-1341.
10. 　Yen TH, Lai PC, Chen CC, et al. Renal involvement in patients with polymyositis and dermatomyositis[J]. Int J Clin Pract, 2005, 59(2): 188-193.
11. 　Horino T, Takao T, Terada Y. IgA nephmpathy in a patient with systemic lupus erythenlatosus[J]. Lupus, 2010, 19(5): 650-654.
12. 　Watanabe M, Fujimoto T, Iwano M, et al. Report of patient of primary, IgA nephropathy and chronic idiopathic thrombocytopenic purpura[J]. Nihon Rinsho Meneki Gakkai Kaishi, 2002, 25(2): 191-198.
13. 　Schwab N, Zozulya AL, Kieseier BC, et al. An imbalance of two functionally and phenotypically different subsets of plasmacytoid dendritic cells characterizes the dysfunctional immune regulation in muhiple sclerosis[J]. J Immunol, 2010, 184(9): 5368-5374.
14. 　Kwan BC, Tam LS, Lai KB, et al. The gene expression of type 17 T helper cell-related cytokines in the urinary sediment of patients with systemic lupus crytheH1atous[J]. Rheumatology (Oxford), 2009, 48(12): 1491-1497.
15. 　Yu H, Huang J, Liu Y, et al. IL-17 contributes to autoimmune hepatitis[J]. J Huazhong Univ Sci Technol Med Sci, 20l0, 30(4): 443-446.
16. 　Hemdan NY, Birkenmeier G, Wichmann G, et al. Interleukin-17-producing T helper cells in autoimmunity[J]. Autoimmun Rev, 2010, 9(11): 785-792.
  1. 1. 　王海燕. 腎臟病學(xué)[M]. 北京: 人民衛(wèi)生出版社, 1997: 708-719.
  2. 2. 　Lee SM, Rao VM, Franklin WA, et al. IgA nephropathy: morphologic predictors of progressive renal disease[J]. Hum Pathol, 1982, 13(4): 314-322.
  3. 3. 　肖俊, 朱玲燕, 陳崴, 等. 調(diào)節(jié)性及輔助性T細(xì)胞在人類IgA腎病中的表達(dá)及意義[J]. 中華腎臟病雜志, 2008, 24(8): 544-549.
  4. 4. 　Layward L, Allen AC, Hattersley JM, et al. Elevation of IgA in IgA nephropathy is localized in the serum and not saliva and is restricted to the IgA1 subclass[J]. Nephrol Dial Transplant, 1993, 8(1): 25-28.
  5. 5. 　Suzuki H, Fan R, Zhang Z, et al. Aberrantly glycosylated IgA1 in IgA nephropathy patients is recognized by IgG antibodies with restricted heterogeneity[J]. J Clin Invest, 2009, 119(6): 1668-1677.
  6. 6. 　Leusehner U. Primary biliary cirrhesis-presentation and diagnosis[J]. Clin Liver Dis, 2003, 7(4): 741-758.
  7. 7. 　Suzuki H, Moldoveanu Z, Hall S, et al. IgA1-secreting cell lines from patients with IgA nephropathy produce aberrantly glycosylated IgA1[J]. J Clin Invest, 2008, 118(2): 629-639.
  8. 8. 　Hazzan R, Mukamel M,Yacobovich J, et al. Risk factors for future development ofsystemic lupus erythematosus in children with idiopathic thrombocytopenic purpura[J]. Pediatr Blood Cancer, 2006, 47(5 Suppl): 657-659.
  9. 9. 　Irie F, Kobayashi M, Hirayama K, et al. Rheumatoid arthritis associated with membranous nephropathy and lgA nephritis with necrotizing lesions[J]. Nephrol Dial Transplant, 1996, 11(7): 1338-1341.
  10. 10. 　Yen TH, Lai PC, Chen CC, et al. Renal involvement in patients with polymyositis and dermatomyositis[J]. Int J Clin Pract, 2005, 59(2): 188-193.
  11. 11. 　Horino T, Takao T, Terada Y. IgA nephmpathy in a patient with systemic lupus erythenlatosus[J]. Lupus, 2010, 19(5): 650-654.
  12. 12. 　Watanabe M, Fujimoto T, Iwano M, et al. Report of patient of primary, IgA nephropathy and chronic idiopathic thrombocytopenic purpura[J]. Nihon Rinsho Meneki Gakkai Kaishi, 2002, 25(2): 191-198.
  13. 13. 　Schwab N, Zozulya AL, Kieseier BC, et al. An imbalance of two functionally and phenotypically different subsets of plasmacytoid dendritic cells characterizes the dysfunctional immune regulation in muhiple sclerosis[J]. J Immunol, 2010, 184(9): 5368-5374.
  14. 14. 　Kwan BC, Tam LS, Lai KB, et al. The gene expression of type 17 T helper cell-related cytokines in the urinary sediment of patients with systemic lupus crytheH1atous[J]. Rheumatology (Oxford), 2009, 48(12): 1491-1497.
  15. 15. 　Yu H, Huang J, Liu Y, et al. IL-17 contributes to autoimmune hepatitis[J]. J Huazhong Univ Sci Technol Med Sci, 20l0, 30(4): 443-446.
  16. 16. 　Hemdan NY, Birkenmeier G, Wichmann G, et al. Interleukin-17-producing T helper cells in autoimmunity[J]. Autoimmun Rev, 2010, 9(11): 785-792.