目的 了解老年2型糖尿病動脈僵硬度與踝臂指數(shù)(ABI)對評價外周動脈硬化的價值。 方法 2010年1月-3月,應(yīng)用超聲、回聲跟蹤技術(shù)和動脈硬化檢測儀檢測80例老年2型糖尿病患者(觀察組)和40例正常老年人(對照組)的頸總動脈內(nèi)中膜厚度(IMT)、僵硬系數(shù)(β)、脈搏波傳導(dǎo)速度(PWVβ)、ABI及動脈斑塊情況。 結(jié)果 與對照組比較,觀察組患者的IMT增厚、β增高、PWVβ增快、ABI降低及動脈斑塊發(fā)生率增多,差異均具有統(tǒng)計學(xué)意義(P<0.001)。 結(jié)論 老年2型糖尿病可導(dǎo)致IMT增厚、動脈僵硬度增高、PWVβ增快、ABI降低及更易發(fā)生動脈粥樣硬化斑塊,這些參數(shù)可以預(yù)測外周動脈粥樣硬化的程度,利用彩色多普勒超聲診斷儀和動脈硬化檢測儀可以較容易得到這些參數(shù),是評價外周動脈粥樣硬化病變一種簡便、易行,有臨床實際意義的方法和手段。
引用本文: 吳冀川,劉天虎,郭華麗,楊靜,王宏宇. 老年2型糖尿病動脈僵硬度和踝臂指數(shù)評價外周動脈硬化. 華西醫(yī)學(xué), 2012, 27(5): 662-664. doi: 復(fù)制
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- 1. 王宏宇. 血管病學(xué)[M].北京:人民軍醫(yī)出版社, 2006.
- 2. Shenkin SD,Bastin ME,MacGillivray TJ, et al. Carotid intima-media thickness and cerebrovascular disease in community- dwelling older people without stroke[J]. Stroke, 2010, 41(9): 2083-2086.
- 3. 曾華鋒,趙小林,余紅麗, 等. 2型糖尿病頸動脈內(nèi)膜中層病變及相關(guān)危險因素分析[J].中國醫(yī)藥導(dǎo)報, 2011, 8(34): 44-46.
- 4. Grobbee DE, Bots ML. Carotid artery intima-media thickness as an indicator of generalized atherosclerosis[J]. J Intern Med, 1994, 236(5): 567-573.
- 5. Pignoli P, Tremohi E, Po1i A, et al. Intima plus medical thickness of the arterial wall: a direct measurement with ultrasound imaging[J].Circulation, 1986, 74(6): 1399-1406.
- 6. Bonithon-Kopp C, Touboul PJ, Berr C, et al. Relation of intima-media thickness to atherosclerotic plaques in carotid arteries. The vascular aging (EVA) study[J]. Arterioscler Thromb Vasc Riol, 1996, 16(2): 310-316.
- 7. 胡大一, 王宏宇. 主動脈僵硬度與急性冠脈事件[J]. 中國醫(yī)刊, 2002, 37(5): 4-5.
- 8. 向林,向光大. 脈搏波傳導(dǎo)速度與糖尿病血管病變關(guān)系研究進(jìn)展[J]. 臨床內(nèi)科雜志, 2010, 27(8): 574-576.
- 9. Asmar R, Benetos A, Topoucfiian J, et al. Assessment of arterial distensibility by automatic pulse wave velocity measurement.Validation and clinical application studies[J]. Hypertension, 1995, 26(3): 485-490.
- 10. 鐘冕, 陳潤鈿, 黃沽明, 等. 影響臂踝脈搏波傳導(dǎo)速度的臨床多因素分析[J]. 現(xiàn)代預(yù)防醫(yī)學(xué), 2009, 36(20): 3820-3822 .
- 11. 胡紹文, 郭瑞林. 實用糖尿病學(xué)[M]. 北京: 人民軍醫(yī)出版社, 2003.
- 12. Ouriel K. Peripheral arterial disease[J]. Lancet, 2001, 358(9289): 1257-1264.
- 13. Peter S. Peripheral arterial disease in people with diabetes: consensus statement recommendsscreening[J]. Clin Diabetes, 2004, 22(4): 179-180 .
- 14. Hasimu B, Li J, Nakayama T, et a1. Ankle braehial index as a marker of atheroselerosis in Chinese patients with high cardiovascular risk[J]. Hypertens Res, 2006, 29(1): 23-28.