• 1四川大學(xué)華西醫(yī)院腎臟內(nèi)科（成都，610041）;2 瀘州醫(yī)學(xué)院附屬醫(yī)院腎臟內(nèi)科;

目的 　探討不同性別IgA腎病患者合并高尿酸血癥的臨床及腎臟病理特點。 方法　采用回顧性研究方法，將2008年1月－2010年12月收治的226例經(jīng)腎活檢確診的原發(fā)性IgA腎病患者分為男性高尿酸血癥組、男性尿酸正常組、女性高尿酸血癥組及女性尿酸正常組4組，統(tǒng)計分析4組的臨床指標及病理指標。 結(jié)果 　高尿酸血癥患病率男性（21.7%）高于女性（11.9%），差異有統(tǒng)計學(xué)意義（P＜0.01），尿檢異常型患病率男性（14.6%）高于女性（4.0%），差異有統(tǒng)計學(xué)意義（P＜0.01），女性LeeⅢ級的患病率（7.1%）高于男性（5.8%），差異有統(tǒng)計學(xué)意義（P＜0.01）；男性高尿酸血癥組的尿素氮高于尿酸正常組（P＜0.05），女性高尿酸血癥組的血尿素氮、血肌酐、胱抑素C、舒張壓、甘油三酯比尿酸正常者明顯增高（P＜0.01），女性高尿酸血癥組的高密度脂蛋白明顯高于男性組（P ＜0.01）。 結(jié)論 　高尿酸血癥是IgA腎病的危險因素，可導(dǎo)致更嚴重的腎功能損害及腎臟病理損害，這種影響在不同性別中存在差異。

引用本文： 蔣易容,文集,張程瓏,樊均明. 不同性別IgA腎病患者合并高尿酸血癥的臨床研究. 華西醫(yī)學(xué), 2012, 27(6): 833-836. doi: 復(fù)制

1. 　Mcgrogan A, Franssen CF, de Vries CS. The incidence of primary glomerulonephritis worldwide： a systemic review of the literature [J].Nephrol Dial Transplant, 2011, 26(2): 414-430.
2. 　Woo KT, Chan CM, Mooi CY, et al. The changing pattern of primary glomerulonephritis in Singapore and other countries over the past 3 decades[J]. Clin Nephrol, 2010, 74(5): 373-384.
3. 　范軍芬, 張史昭, 魯科達, 等. IgA腎病伴高尿酸血癥患者流行病學(xué)及臨床病理分析[J].臨床醫(yī)學(xué), 2008, 28(2): 103-104.
4. 　姜雪, 許菲菲, 章建娜, 等. IgA腎病并發(fā)高尿酸血癥患者5年隨訪研究[J].中華腎臟病雜志, 2011, 27(1): 53-54.
5. 　Ghani AA, Al Waheeb S, Al Homoud E, et al. Clinical and histopathological spectrum of IgA nephropathy in Kuwait[J]. Ann Saudi Med, 2011, 31(2): 152-157.
6. 　Le W, Liang S, Hu Y, et al. Long-term renal survival and related risk factors in patients with IgA nephropathy: results from a cohort of 1155 cases in a Chinese adult population[J]. Nephrol Dial Transplant, 2012, 27(4): 1479-1485.
7. 　中國醫(yī)師協(xié)會心血管內(nèi)科醫(yī)師分會, 中國醫(yī)師協(xié)會循證醫(yī)學(xué)專業(yè)委員會.無癥狀高尿酸血癥合并心血管疾病診治建議中國專家共識[J] . 中國全科醫(yī)學(xué), 2010, 13(11): 1145-1149.
8. 　張馨, 黎磊石, 孫曄, 等.不同類型IgA腎病的流行病學(xué)及臨床特點分析[J].腎臟病與透析腎移植雜志, 2006, 15(4): 305-310.
9. 　Lee SM, Rao VM, Franklin WA, et al. IgA nephropathy: morphologic predictors of progressive renal disease [J]. Hum Pathol, 1982, 13(4): 314-322.
10. 　Ohno I. Relationship between hyperuricemia and chronic kidney disease [J]. Nucleos Necleot Nucl, 2011, 30(12): 1039-1044.
11. 　Shi YJ, Chen W, Li ZB, et al. Clinical outcome of hyperuricemia in IgA nephropathy: a retrospective cohort study and randomized controlled trial[J]. Kidney Blood Press Res, 2012, 35(3): 153-160.
12. 　Gersch C, Palii SP, Kim KM, et al. Inactivation of nitric oxide by uric acid[J]. Nucleos Necleot Nucl, 2008, 27(8):967-978.
13. 　Albertoni G, Maquiqussa E, Pessoa E, et al. Soluble uric acid increases intracellular calcium through an angiotensinⅡ-dependent mechanism in immaortalized human mesangial cells[J]. Exp Biol Med, 2010, 235(7): 825-832.
14. 　Hovind P, Rossing P, Johnson RJ, et al. Serum uric acid as a new player in the development of diabetic nephropathy[J]. J Ren Nutri, 2011, 21(1): 124-127.
15. 　崔明姬, 張寶紅, 肖慶飛, 等.高尿酸血癥與IgA腎病臨床病例的相關(guān)性分析[J].中華內(nèi)科雜志, 2011, 50(8): 659-663.
16. 　Seeman T, Pohl M, John U, et al. Ambulatory blood pressure, proteinuria and uric acid in children with IgA nephropathy and their correlation with histopathological findings[J]. Kidney Blood Press Res, 2008, 31(5): 337-342.
  1. 1. 　Mcgrogan A, Franssen CF, de Vries CS. The incidence of primary glomerulonephritis worldwide： a systemic review of the literature [J].Nephrol Dial Transplant, 2011, 26(2): 414-430.
  2. 2. 　Woo KT, Chan CM, Mooi CY, et al. The changing pattern of primary glomerulonephritis in Singapore and other countries over the past 3 decades[J]. Clin Nephrol, 2010, 74(5): 373-384.
  3. 3. 　范軍芬, 張史昭, 魯科達, 等. IgA腎病伴高尿酸血癥患者流行病學(xué)及臨床病理分析[J].臨床醫(yī)學(xué), 2008, 28(2): 103-104.
  4. 4. 　姜雪, 許菲菲, 章建娜, 等. IgA腎病并發(fā)高尿酸血癥患者5年隨訪研究[J].中華腎臟病雜志, 2011, 27(1): 53-54.
  5. 5. 　Ghani AA, Al Waheeb S, Al Homoud E, et al. Clinical and histopathological spectrum of IgA nephropathy in Kuwait[J]. Ann Saudi Med, 2011, 31(2): 152-157.
  6. 6. 　Le W, Liang S, Hu Y, et al. Long-term renal survival and related risk factors in patients with IgA nephropathy: results from a cohort of 1155 cases in a Chinese adult population[J]. Nephrol Dial Transplant, 2012, 27(4): 1479-1485.
  7. 7. 　中國醫(yī)師協(xié)會心血管內(nèi)科醫(yī)師分會, 中國醫(yī)師協(xié)會循證醫(yī)學(xué)專業(yè)委員會.無癥狀高尿酸血癥合并心血管疾病診治建議中國專家共識[J] . 中國全科醫(yī)學(xué), 2010, 13(11): 1145-1149.
  8. 8. 　張馨, 黎磊石, 孫曄, 等.不同類型IgA腎病的流行病學(xué)及臨床特點分析[J].腎臟病與透析腎移植雜志, 2006, 15(4): 305-310.
  9. 9. 　Lee SM, Rao VM, Franklin WA, et al. IgA nephropathy: morphologic predictors of progressive renal disease [J]. Hum Pathol, 1982, 13(4): 314-322.
  10. 10. 　Ohno I. Relationship between hyperuricemia and chronic kidney disease [J]. Nucleos Necleot Nucl, 2011, 30(12): 1039-1044.
  11. 11. 　Shi YJ, Chen W, Li ZB, et al. Clinical outcome of hyperuricemia in IgA nephropathy: a retrospective cohort study and randomized controlled trial[J]. Kidney Blood Press Res, 2012, 35(3): 153-160.
  12. 12. 　Gersch C, Palii SP, Kim KM, et al. Inactivation of nitric oxide by uric acid[J]. Nucleos Necleot Nucl, 2008, 27(8):967-978.
  13. 13. 　Albertoni G, Maquiqussa E, Pessoa E, et al. Soluble uric acid increases intracellular calcium through an angiotensinⅡ-dependent mechanism in immaortalized human mesangial cells[J]. Exp Biol Med, 2010, 235(7): 825-832.
  14. 14. 　Hovind P, Rossing P, Johnson RJ, et al. Serum uric acid as a new player in the development of diabetic nephropathy[J]. J Ren Nutri, 2011, 21(1): 124-127.
  15. 15. 　崔明姬, 張寶紅, 肖慶飛, 等.高尿酸血癥與IgA腎病臨床病例的相關(guān)性分析[J].中華內(nèi)科雜志, 2011, 50(8): 659-663.
  16. 16. 　Seeman T, Pohl M, John U, et al. Ambulatory blood pressure, proteinuria and uric acid in children with IgA nephropathy and their correlation with histopathological findings[J]. Kidney Blood Press Res, 2008, 31(5): 337-342.