【摘要】 目的 觀察依托咪酯乳劑復(fù)合舒芬太尼用于全麻下喉罩置入的血流動(dòng)力學(xué)變化。 方法 選擇2009年4月-2010年2月間,46例需全麻手術(shù)、適合使用喉罩,美國(guó)麻醉醫(yī)師協(xié)會(huì)(ASA)Ⅰ~Ⅱ級(jí),年齡18~60歲的患者,隨機(jī)分為兩組:依托咪酯乳劑組(E組)23 例,靜脈推注咪達(dá)唑侖0.05 mg/kg,依托咪酯乳劑0.3 mg/kg;依托咪酯乳劑+舒芬太尼組(ES組)23 例,靜脈推注咪達(dá)唑侖0.05 mg/kg,依托咪酯乳劑0.15 mg/kg,加舒芬太尼0.5 mg/kg,誘導(dǎo)后置入喉罩,記錄患者誘導(dǎo)前、用藥后1 min、喉罩置入后1 min的心率(HR)、平均動(dòng)脈壓(MAP)以及評(píng)估喉罩置入條件的6項(xiàng)指標(biāo)(張口困難分級(jí)、置入喉罩困難分級(jí)、舌咽反射、干咳干嘔反射、肢動(dòng)反應(yīng)及喉痙攣分級(jí)),同時(shí)記錄呼吸暫停時(shí)間。 結(jié)果 ES組能提供更好的喉罩置入條件,且能減少舌咽反射和肢體反應(yīng), 更能保證喉罩置入時(shí)血流動(dòng)力學(xué)的穩(wěn)定。 結(jié)論 依托咪酯乳劑復(fù)合舒芬太尼能為全麻喉罩置入時(shí)提供更好的條件,且能保證更好的血流動(dòng)力學(xué)穩(wěn)定。
【Abstract】 Objective To investigate the hemodynamics changes when etomidate combined with sufentanil was applied for laryngeal mask airway insertion under the general anaesthesia. Methods From April 2009 to February 2010, 46 patients requiring general anesthesia using laryngeal mask airway (LMA) (American Society of Anesthesiologists (ASA)Ⅰ-Ⅱ) aged 18-60 were randomly divided into two groups: 23 in etomidate emulsion group (group E) underwent the intravenous injection with midazolm (0.3 mg/kg) and etomidate (0.05 mg/kg); 23 in etomidate emulsion + sufentanil group (group ES) underwent the intravenous injection with etomidate (0.15 mg/kg), midazolm (0.05 mg/kg), and sufentanil 0.5 mg/kg. The patients were evaluated by six indexes of LMA insertion (mouth opening, swallowing reflex, cough reflex,vomiting reflex, body motion, and laryngospasm classification). After the anesthesia induction, LMA was inserted. The blood pressure (BP), heart rate (HR), and mean arterial pressure (MAP) were recorded before anesthesia induction one minute after the injection and one minute after LMA insertion. Meanwhile, the apnea time was recorded. Results Compared with group E, group ES offered better anesthesia for LMA insertion, less swallowing reflex and body motion, and more stable haemodynamics. Conclusion Etomidate combined with sufentanil provides good condition for LMA insertion under the general anaesthesia with steady haemodynamics.
引用本文: 王峰,李家寬. 依托咪酯乳劑復(fù)合舒芬太尼用于全麻喉罩置入的臨床觀察. 華西醫(yī)學(xué), 2011, 26(2): 232-234. doi: 復(fù)制
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9. | 汪蕾, 董鐵立. 全麻誘導(dǎo)期丙泊酚、依托咪酯、咪唑安定對(duì)血液動(dòng)力學(xué)的影響[J].醫(yī)藥論壇雜志, 2010, 31(11): 62-63. |
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- 1. 徐啟明. 臨床麻醉學(xué)[M]. 2版. 北京: 人民衛(wèi)生出版社, 2006: 58-60.
- 2. 左明章, 華震. 喉罩的臨床應(yīng)用進(jìn)展[C]. 廣州: 2005年中華醫(yī)學(xué)會(huì)全國(guó)麻醉學(xué)會(huì)年會(huì)論文匯編, 2005: 190-196.
- 3. 楊寧, 左明章, 劉國(guó)林, 等. 國(guó)產(chǎn)依托咪酯乳劑用于全身麻醉誘導(dǎo)的多中心研究[J].臨床麻醉學(xué)雜志,2008, 24(5): 418-420.
- 4. 孟春, 梁禹, 李恒林, 等. 喉罩及靶控輸注應(yīng)用于神經(jīng)外科術(shù)中喚醒麻醉[J]. 白求恩軍醫(yī)學(xué)院學(xué)報(bào), 2006, 4(2): 78-79.
- 5. 姚尚龍, 王俊科. 臨床麻醉學(xué)[M]. 北京: 人民衛(wèi)生出版社, 2004: 54.
- 6. 徐江玲. 喉罩在婦科腹腔鏡手術(shù)麻醉中的應(yīng)用[J]. 海南醫(yī)學(xué), 2006, 17(4): 19-21.
- 7. 華震, 周淑珍, 王楊, 等. Proseal喉罩在腹腔鏡膽囊切除手術(shù)中的應(yīng)用[J]. 中國(guó)臨床醫(yī)生, 2007, 35(1): 43-44.
- 8. 李軍祥, 宋華勇, 劉娟, 等. 依托咪酯持續(xù)輸注用于全身麻醉誘導(dǎo)和持續(xù)輸注維持的臨床觀察[J].華西醫(yī)學(xué), 2009, 24(10):2543-2546.
- 9. 汪蕾, 董鐵立. 全麻誘導(dǎo)期丙泊酚、依托咪酯、咪唑安定對(duì)血液動(dòng)力學(xué)的影響[J].醫(yī)藥論壇雜志, 2010, 31(11): 62-63.
- 10. Thomson IR, Henderson BT, Singh K, et al. Concentration-responserelationships for fentanyl and sufentanil in patients undergoing coronary artery bypass grafting[J]. Anesthesiology, 1998, 89(4): 852-861.
- 11. 王義軍, 卿恩明, 尹雁, 等. 異丙酚和依托咪酯在全麻誘導(dǎo)期對(duì)微循環(huán)灌注量的影響[J].中華麻醉學(xué)雜志, 1997, 17(10): 579-581.
- 12. 吳新民. 靜脈麻醉的一些進(jìn)展[J]. 中華麻醉學(xué)雜志, 2001, 21(10): 586-587.