【摘要】 目的 觀察聚明膠肽注射液和羥乙基淀粉（130/0.4）氯化鈉注射液對創(chuàng)傷失血性休克患者的臨床治療效果。 方法 將2006年6月-2008年10月創(chuàng)傷失血性休克患者32例隨機分為聚明膠肽組和羥乙基淀粉組，每組16例。搶救時除采用止血、擴容、糾酸等綜合措施外，分別輸入聚明膠肽注射液和羥乙基淀粉（130/0.4）氯化鈉注射液1 500 mL。兩組均監(jiān)測血壓、尿量和血氣分析指標，比較兩組指標恢復正常以及所需的時間。 結(jié)果 聚明膠肽組與羥乙基淀粉組上述指標恢復正常及所需的時間無差異，兩組生存率、致殘率及并發(fā)癥均無差異。 結(jié)論 聚明膠肽注射液用于創(chuàng)傷失血性休克的療效與羥乙基淀粉（130/0.4）氯化鈉注射液相當。
【Abstract】 Objective To observe the clinical effects of polygeline injection and hydroxyethyl starch(130/0.4) NaCl injection (HES)on the traumatic hemorrhagic shock. Methods A total of 32 patients with traumatic hemorrhagic shock were randomly divided into polygeline injection group and HES group,with 16 patients in each. The same measures such as hemstasis, expanding blood volume, correction of acid base disturbance and so on were adopted in the both groups. The patients in the polygeline injection group and HES group were respectively treated with polygeline injection and HES NaCl injection in a dose of 1500 mL by intravenous infusion. The time from injection to the recovery of BP, urinary output, and blood gas to normal level was recorded. Results BP, urinary output, and blood gas were all improved significantly, there was no significant difference between the two groups (P gt;0.05). Conclusion The clinical effect of polygeline injection on stabilizing BP and improving microcirculation appears comparable to that of HES.
引用本文： 李晉波,李璐,左可見. 聚明膠肽與羥乙基淀粉在創(chuàng)傷失血性休克中的應(yīng)用比較. 華西醫(yī)學, 2010, 25(8): 1415-1417. doi: 復制
版權(quán)信息： ?四川大學華西醫(yī)院華西期刊社《華西醫(yī)學》版權(quán)所有，未經(jīng)授權(quán)不得轉(zhuǎn)載、改編
| 1. | 王戰(zhàn)朝. 現(xiàn)代創(chuàng)傷與急救[M]. 北京: 科學技術(shù)出版社, 1996: 39-42. |
| 2. | 王迪得. 病理生理學[M]. 北京: 人民衛(wèi)生出版社, 1994: 302-307. |
| 3. | 朱敬明, 劉存明, 陸琳, 等. 羥乙基淀粉對血液流變學及凝血功能的影響[J]. 臨床麻醉學雜志, 2001, 17(4): 194. |
| 4. | Schimetta W, Laubenthal H, Sirtl CJ. Comparative efficacy of hydroxyethyl starch & haemaccel in the treatment of severe ovarian hyperstimulation syndrome[J]. Fertil Steril, 2003, 79(3): 660-666. |
| 5. | 馬騏, 張濤. 最新一代血漿代用品-中分子羥乙基淀粉(賀斯). 德國醫(yī)學, 1999, 16(4): 241-242. |
| 6. | 陳瑛琪, 岳云, 吳延, 等. 賀斯急性等容血液稀釋對手術(shù)患者組織器官的影響[J]. 中華麻醉學雜志, 2001, 21(5): 316-317. |
| 7. | 徐雪, 趙硯麗, 程會平, 等. 人工血漿代用品對凝血和纖溶功能的影響[J]. 中華麻醉學雜志, 2000, 20(9): 520-523. |
- 1. 王戰(zhàn)朝. 現(xiàn)代創(chuàng)傷與急救[M]. 北京: 科學技術(shù)出版社, 1996: 39-42.
- 2. 王迪得. 病理生理學[M]. 北京: 人民衛(wèi)生出版社, 1994: 302-307.
- 3. 朱敬明, 劉存明, 陸琳, 等. 羥乙基淀粉對血液流變學及凝血功能的影響[J]. 臨床麻醉學雜志, 2001, 17(4): 194.
- 4. Schimetta W, Laubenthal H, Sirtl CJ. Comparative efficacy of hydroxyethyl starch & haemaccel in the treatment of severe ovarian hyperstimulation syndrome[J]. Fertil Steril, 2003, 79(3): 660-666.
- 5. 馬騏, 張濤. 最新一代血漿代用品-中分子羥乙基淀粉(賀斯). 德國醫(yī)學, 1999, 16(4): 241-242.
- 6. 陳瑛琪, 岳云, 吳延, 等. 賀斯急性等容血液稀釋對手術(shù)患者組織器官的影響[J]. 中華麻醉學雜志, 2001, 21(5): 316-317.
- 7. 徐雪, 趙硯麗, 程會平, 等. 人工血漿代用品對凝血和纖溶功能的影響[J]. 中華麻醉學雜志, 2000, 20(9): 520-523.