• 1.四川省婦幼保健院，四川成都 610031; 2.四川大學(xué)華西第二醫(yī)院，四川成都 610041;

目的：研究細(xì)胞間粘附分子-1(ICAM-1)和基質(zhì)金屬蛋白酶9(MMP-9)在足月及早產(chǎn)分娩發(fā)動(dòng)前后孕婦子宮下段肌層中的表達(dá)，探討ICAM-1和MMP-9在足月及早產(chǎn)分娩中的作用。方法：用免疫組織化學(xué)SP法檢測(cè)ICAM-1和MMP-9在足月及早產(chǎn)分娩發(fā)動(dòng)前后各組孕婦子宮下段肌層中的表達(dá)。結(jié)果：足月及早產(chǎn)分娩發(fā)動(dòng)組中ICAM-1在子宮下段肌層血管內(nèi)皮細(xì)胞上的表達(dá)均顯著強(qiáng)于分娩未發(fā)動(dòng)組。MMP-9在分娩發(fā)動(dòng)子宮下段間質(zhì)中的表達(dá)也均顯著強(qiáng)于分娩發(fā)動(dòng)前。分娩發(fā)動(dòng)后白細(xì)胞浸潤(rùn)間質(zhì)較分娩發(fā)動(dòng)前明顯增加。結(jié)論：ICAM-1和MMP-9在足月及早產(chǎn)分娩發(fā)動(dòng)中顯著增加，它們?cè)诜置浒l(fā)動(dòng)中具有重要作用。早產(chǎn)發(fā)生機(jī)制與足月分娩發(fā)動(dòng)相似，類似于急性炎癥反應(yīng)。

引用本文： 段瑞岐,曾蔚越,徐秀梅. ICAM-1和MMP-9在足月及早產(chǎn)分娩中的作用研究. 華西醫(yī)學(xué), 2009, 24(2): 325-327. doi: 復(fù)制

版權(quán)信息： ?四川大學(xué)華西醫(yī)院華西期刊社《華西醫(yī)學(xué)》版權(quán)所有，未經(jīng)授權(quán)不得轉(zhuǎn)載、改編

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9. Helen Fe，Huiling Ji，Jessie W，et al.Effects of selective and nonselective PGE2 receptor agonists on cervical tensile strength and collagen organization and microstructure in the pregnant rat at term[J].Am J Obstet Gynecol，2005，192：753-760.
  1. 1. Winkler M，Ruck P，Horny HP.Expression of cell adhesion molecules by endothelium in the human lower uterine segment during parturition at term[J].Am J Obstet Gynecol，1998，178(3)：557-561..
  2. 2. Thomson AJ，Telfer JF，Young A，et al.Leukocytes infiltrate the myometrium during human parturition：further evidence that labour is an inflammatory process[J].Hum Reprod，1999，14(1)：229..
  3. 3. Winkler M，Rath W.Changes in the cervical extracellular matrix during pregnancy and parturition[J].J Perinat Med，1999，27(1)：45..
  4. 4. Vainer B，Nielsen OH.Correlation between circulating soluble ICAM1 and predniso loneinducedamelio ration of ulcerative colitis[J].Scand J Gastroenterol，2003，38(3)：283..
  5. 5. Weiss A，Goldman S，Ben Shlomo I，et al.Mechanisms of matrixmetallo proteinase9 and matrix metallo proteinase2 inhibition by Nacetylcysteine in the human term decidua and fetalmembranes[J].Am J Obstet Gynecol，2003，189：1758-1763..
  6. 6. Stygar D，Wang H，Stjernholm VY，et al.Increased level of matrix metalloproteinase 2 and 9 in the ripening process of the human cervix[J].Biol Reprod，2002，67(3)：889-894..
  7. 7. Junquiera LCU，Zugaib M，Montes GS.Morphological and histochemical evidence for the occurrence of collagenolysis and for the role of the neutrophilic polymorphonuclear leukocytes during cervical dilatation[J].Am J Obstet Gynecol，1980，138：273-281..
  8. 8. Winkler M，DC Fischer，P Ruck，et al.Interleukin8 associated increase in the number of neutrophilic granulocytes in the cervical stroma as a basic mechanism of cervical dilatation duing parturition at term[J].Geburtsh Frauenheilk，1997，57：300..
  9. 9. Helen Fe，Huiling Ji，Jessie W，et al.Effects of selective and nonselective PGE2 receptor agonists on cervical tensile strength and collagen organization and microstructure in the pregnant rat at term[J].Am J Obstet Gynecol，2005，192：753-760.