• 1.四川大學(xué)華西醫(yī)院心內(nèi)科,四川成都 610041;2.四川大學(xué)華西第二醫(yī)院分子與轉(zhuǎn)化醫(yī)學(xué)實(shí)驗(yàn)室, 四川成都 610041;

目的:本文通過(guò)研究白介素23受體(IL-23R)基因多態(tài)性與擴(kuò)張型心肌病(DCM)的相關(guān)性,探討DCM患者的免疫遺傳學(xué)發(fā)病機(jī)制. 方法:采用PCR-RFLP方法測(cè)定DCM患者和正常對(duì)照者IL-23R基因rs7517847位點(diǎn)的單核苷酸多態(tài)性. 用卡方檢驗(yàn)比較病例組與對(duì)照組之間基因型頻率和等位基因頻率的統(tǒng)計(jì)學(xué)差異。結(jié)果:IL-23R基因rs7517847位點(diǎn)單核苷酸多態(tài)基因型和等位基因頻率在DCM組與正常對(duì)照組之間無(wú)差異。結(jié)論:本研究未發(fā)現(xiàn)IL-23R基因rs7517847位點(diǎn)多態(tài)性與DCM相關(guān)。

引用本文： 陳宇,彭瑛,周斌,李晨,丁尋實(shí),何星球,饒莉. 白介素23受體基因多態(tài)性與擴(kuò)張型心肌病的相關(guān)研究. 華西醫(yī)學(xué), 2009, 24(4): 870-872. doi: 復(fù)制

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  2. 2. FU M. Autoimmunity in idiopathic dilated cardiomyopathy: from patients to molecules and back to patients[J]. Int J Cardiol, 2006, 112:1..
  3. 3. PARHAM C, CHIRICA M, TIMANS J, et al. A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R[J]. J Immunol, 2002, 168(11):5699-5708..
  4. 4. OPPMANN B, LESLEY R, BLOM B, et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12[J]. Immunity,2000,13:715-725..
  5. 5. PARK H, LI ZX, YANG XO, et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing Interleukin 17[J]. Nat lmmunol, 2005, 6(11):1133-1141..
  6. 6. LANGRISH CL, CHEN Y, BLUMENSCHEIN WM, et al. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation[J].J Exp Med, 2005, 201: 233-240..
  7. 7. SONDEREGGER I, ROHN, TA, KURRER MO, et al.Neutralization of IL-17 by active vaccination inhibits IL-23-dependent autoimmune myocarditis[J]. Eur J Immunol, 2006, 36(11): 2849-2856..
  8. 8. RANGACHARI M,MAUERMANN N,MARTY RR,et al.T-bet negatively regulates autoimmune myocarditis by suppressing local production of interleukin 17[J].J Exp Med, 2006, 203(8): 2009 -2019..