• 四川大學(xué)華西醫(yī)院消化內(nèi)科, 四川成都 610041;

目的:探討幽門螺桿菌(Hp)感染與各種常見上消化道疾病的關(guān)系。 方法:回顧性地分析了2008年于我院采用快速尿素酶試驗(yàn)(RUT)檢測Hp的6636例門診及住院患者Hp感染情況,及與性別、年齡、病種的關(guān)系。結(jié)果:6636例患者中,Hp陽性3248例,檢出率為48.9%;其中男性4391例,檢出率為49.97%,女性2 245例,檢出率為46.9%,男性略高于女性,差異有統(tǒng)計(jì)學(xué)意義(P lt;0.05);20～29歲和30～39歲這兩個(gè)年齡段Hp檢出率最高,分別為58.4%和54.6%, lt;20歲Hp檢出率最低(38.8%),各組間差異有統(tǒng)計(jì)學(xué)意義(P lt;0.01);各種常見的上消化道疾病,復(fù)合性潰瘍和上消化道惡性腫瘤Hp檢出率最高,分別為86.2%和84.1%,其次是幽門管潰瘍和十二指腸潰瘍,檢出率分別為54.2%和51.9%,慢性胃炎、殘胃炎、胃潰瘍和食管靜脈曲張Hp檢出率分別為46.9%、40.0%、36.6%和34.2%,各組間的差異有顯著的統(tǒng)計(jì)學(xué)意義(P lt;0.005)。 結(jié)論:本組資料Hp總檢出率為48.9%,男性略高于女性,慢性胃炎、消化性潰瘍和上消化道惡性腫瘤與Hp感染密切相關(guān),尤以復(fù)合性潰瘍和上消化道惡性腫瘤更為顯著。

引用本文： 于衛(wèi)華,王一平. Hp感染與上消化道疾病關(guān)系的初步探討. 華西醫(yī)學(xué), 2009, 24(6): 1447-1449. doi: 復(fù)制

1. 胡品津,胡伏蓮.中華醫(yī)學(xué)會第四次幽門螺桿菌全國學(xué)術(shù)會議紀(jì)要[J].中華消化雜志,2005,25(11):698-699.
2. 任書林,孫琦,趙宏宇.幽門螺桿菌感染與慢性胃炎、消化性潰瘍及胃癌的發(fā)病關(guān)系[J].內(nèi)蒙古民族大學(xué)學(xué)報(bào)(自然科學(xué)版),2002,17(6):537-541.
3. SHI R, XU S, ZHANG H, et al. Prevalence and risk factors for Helicobacter pylori infection in Chinese populations[J]. Helicobacter,2008,13(2):157-165.
4. BROWN LM.Helicobacter pylori: Epidemiology and Routes of Transmission[J]. Epidemiol Rev,2000,22(2):283-297.
5. 饒正偉,馮剛,馮軼,黃芝敏.5000例消化系統(tǒng)疾病患者胃鏡檢查結(jié)果和HP感染情況的調(diào)查分析[J].貴州醫(yī)藥,2008,32(4):361-363.
6. 李書印.南陽市常見上消化道疾病患者HP感染流行病學(xué)初步調(diào)查研究[J].中國自然醫(yī)學(xué)雜志,2008,10(5):371-373.
7. CHENG H,HU F,ZHANG L, et al.Prevalence of Helicobacter pylori infection and identification of risk factors in rural and urban Beijing, China[J]. Helicobacter, 2009,14(2):128-133.
8. 婁文輝,張娜,楊瑞權(quán).600例老年人幽門螺旋桿菌感染與上消化道疾病的關(guān)系[J].吉林醫(yī)學(xué),2007,28(9):1087-1088.
9. 張琴,呂鳴,楊龍,呂有靈.幽門螺旋桿菌菌感染與老年人上消化道疾病的關(guān)系[J].中華消化雜志,2005,25(11):697.
10. DE MARTEL C, PARSONNET J.Helicobacter pylori Infection and Gender: A MetaAnalysis of PopulationBased Prevalence Surveys[J]. Dig Dis Sci,2006,51(12): 2292–2301.
11. WU HC,TUO BG,WU WM, et al.Prevalence of Peptic Ulcer in Dyspeptic Patients and the Influence of Age,Sex,and Helicobacter pylori Infection[J].Dig Dis Sci,2008, 53(10):2650–2656.
12. ZHANG Q,LI Y, LI X, et al. PARP1 Val762Ala polymorphism, CagA+ H. pylori infection and risk for gastric cancer in Han Chinese population[J].Mol Biol Rep,2008,21.
13. SUGIYAMA T.Development of gastric cancer associated with Helicobacter pyloriInfection[J].Cancer Chemother Pharmacol,2004,54(Suppl 1):S12-20.
14. OHATA H,KITAUCHI S,YOSHIMURA N, et al. Progression of chronic atrophic gastritis associated with Helicobacter pylori infection increases risk of gastric cancer [J].Int J Cancer,2004,109(1):138-143.
15. ALEMPIJEVI T,KRSTI M,ANTONI V, et al. Frequency of Helicobacter pylori infection in patients with liver cirrhosis[J].Srp Arh Celok Lek,2007,135 (9-10):536-540.
16. 王英凱,金晶蘭,樸云峰等.幽門螺桿菌感染與肝硬化[J].臨床肝膽病雜志,2006,22(5):359-360.
17. KIM DJ, KIM HY, KIM SJ. Helicobacter pylori infection and peptic ulcer disease in patients with liver cirrhosis[J]. Korean J Intern Med, 2008,23(1):16-21.
18. 周麗雅,沈祖堯,林三仁.根除幽門螺桿菌對胃黏膜炎癥變化的人群隨訪研究[J].中華內(nèi)科雜志,2003,42(3):162-164.
  1. 1. 胡品津,胡伏蓮.中華醫(yī)學(xué)會第四次幽門螺桿菌全國學(xué)術(shù)會議紀(jì)要[J].中華消化雜志,2005,25(11):698-699.
  2. 2. 任書林,孫琦,趙宏宇.幽門螺桿菌感染與慢性胃炎、消化性潰瘍及胃癌的發(fā)病關(guān)系[J].內(nèi)蒙古民族大學(xué)學(xué)報(bào)(自然科學(xué)版),2002,17(6):537-541.
  3. 3. SHI R, XU S, ZHANG H, et al. Prevalence and risk factors for Helicobacter pylori infection in Chinese populations[J]. Helicobacter,2008,13(2):157-165.
  4. 4. BROWN LM.Helicobacter pylori: Epidemiology and Routes of Transmission[J]. Epidemiol Rev,2000,22(2):283-297.
  5. 5. 饒正偉,馮剛,馮軼,黃芝敏.5000例消化系統(tǒng)疾病患者胃鏡檢查結(jié)果和HP感染情況的調(diào)查分析[J].貴州醫(yī)藥,2008,32(4):361-363.
  6. 6. 李書印.南陽市常見上消化道疾病患者HP感染流行病學(xué)初步調(diào)查研究[J].中國自然醫(yī)學(xué)雜志,2008,10(5):371-373.
  7. 7. CHENG H,HU F,ZHANG L, et al.Prevalence of Helicobacter pylori infection and identification of risk factors in rural and urban Beijing, China[J]. Helicobacter, 2009,14(2):128-133.
  8. 8. 婁文輝,張娜,楊瑞權(quán).600例老年人幽門螺旋桿菌感染與上消化道疾病的關(guān)系[J].吉林醫(yī)學(xué),2007,28(9):1087-1088.
  9. 9. 張琴,呂鳴,楊龍,呂有靈.幽門螺旋桿菌菌感染與老年人上消化道疾病的關(guān)系[J].中華消化雜志,2005,25(11):697.
  10. 10. DE MARTEL C, PARSONNET J.Helicobacter pylori Infection and Gender: A MetaAnalysis of PopulationBased Prevalence Surveys[J]. Dig Dis Sci,2006,51(12): 2292–2301.
  11. 11. WU HC,TUO BG,WU WM, et al.Prevalence of Peptic Ulcer in Dyspeptic Patients and the Influence of Age,Sex,and Helicobacter pylori Infection[J].Dig Dis Sci,2008, 53(10):2650–2656.
  12. 12. ZHANG Q,LI Y, LI X, et al. PARP1 Val762Ala polymorphism, CagA+ H. pylori infection and risk for gastric cancer in Han Chinese population[J].Mol Biol Rep,2008,21.
  13. 13. SUGIYAMA T.Development of gastric cancer associated with Helicobacter pyloriInfection[J].Cancer Chemother Pharmacol,2004,54(Suppl 1):S12-20.
  14. 14. OHATA H,KITAUCHI S,YOSHIMURA N, et al. Progression of chronic atrophic gastritis associated with Helicobacter pylori infection increases risk of gastric cancer [J].Int J Cancer,2004,109(1):138-143.
  15. 15. ALEMPIJEVI T,KRSTI M,ANTONI V, et al. Frequency of Helicobacter pylori infection in patients with liver cirrhosis[J].Srp Arh Celok Lek,2007,135 (9-10):536-540.
  16. 16. 王英凱,金晶蘭,樸云峰等.幽門螺桿菌感染與肝硬化[J].臨床肝膽病雜志,2006,22(5):359-360.
  17. 17. KIM DJ, KIM HY, KIM SJ. Helicobacter pylori infection and peptic ulcer disease in patients with liver cirrhosis[J]. Korean J Intern Med, 2008,23(1):16-21.
  18. 18. 周麗雅,沈祖堯,林三仁.根除幽門螺桿菌對胃黏膜炎癥變化的人群隨訪研究[J].中華內(nèi)科雜志,2003,42(3):162-164.