• 1.昆明醫(yī)學(xué)院第二附屬醫(yī)院急診外科（昆明650101）;;
  • 2.云南省第一人民醫(yī)院普通外科（昆明650000）;

目的 　研究生長激素受體(GHR)在人胃癌組織中的表達(dá)情況。
方法 　采用免疫組織化學(xué)法檢測57例胃癌標(biāo)本及其遠(yuǎn)端正常組織中GHR的表達(dá)。
結(jié)果 　胃癌組織中GHR表達(dá)陽性率為80.7%(46/57)，遠(yuǎn)斷端正常組織中GHR表達(dá)陽性率為70.2%(40/57)，兩者比較差異無統(tǒng)計(jì)學(xué)意義(P gt;0.05)。胃癌組織中GHR的表達(dá)與腫瘤分化程度、組織學(xué)類型、性別和年齡均無關(guān)(P gt;0.05)。
結(jié)論 　胃癌組織和遠(yuǎn)端正常組織中GHR的表達(dá)基本一致。

引用本文： 梁道明,楊蔚,周東,廖庚進(jìn),陳嘉勇. 胃癌組織中生長激素受體的表達(dá). 中國普外基礎(chǔ)與臨床雜志, 2009, 16(3): 208-210. doi: 復(fù)制

1. Biolo G, Iscra F, Bosutti A, et al. Growth hormone decreases muscle glutamine production and stimulates protein synthesis in hypercatabolic patients [Ｊ]. Am J Physiol Endocrinol Metab, 2000; 279(2):E323.
2. Shen XY, Holt RI, Miell JP, et al. Cirrhotic liver expresses low levels of the full-length and truncated growth hormone receptors [Ｊ]. J Clin Endocrinol Metab, 1998; 83(7):2532.
3. Divisova J, Kuiatse I, Lazard Z, et al. The growth hormone receptor antagonist pegvisomant blocks both mammary gland development and MCF-7 breast cancer xenograft growth [Ｊ]. Breast Cancer Res Treat, 2006; 98(3):315.
4. 楊小東, 劉福坤, 許哲, 等. 生長激素受體在結(jié)直腸癌中的表達(dá)及其意義 [Ｊ]. 中華胃腸外科雜志, 2005; 8(3):252.
5. Wu X, Wan M, Li G, et al. Growth hormone receptor overexpression predicts response of rectal cancers to pre-operative radiotherapy [Ｊ]. Eur J Cancer, 2006; 42(7):888.
6. Scharf JG, Dombrowski F, Ramadori G. The IGF axis and hepatocarcinogenesis [Ｊ]. Mol Pathol, 2001; 54(3):138.
7. van Garderen E, Schalken JA. Morphogenic and tumorigenic potentials of the mammary growth hormone/growth hormone receptor system [Ｊ]. Mol Cell Endocrinol, 2002; 197(1-2):153.
8. Weiss-Messer E, Merom O, Adi A, et al. Growth hormone (GH) receptors in prostate cancer: gene expression in human tissues and cell lines and characterization, GH signaling and androgen receptor regulation in LNCaP cells [Ｊ]. Mol Cell Endocrinol, 2004; 220(1-2):109.
9. 吳曉宇, 許哲, 陳徹, 等. 生長激素受體在結(jié)直腸癌發(fā)生過程中表達(dá)上調(diào) [Ｊ]. 腸外與腸內(nèi)營養(yǎng), 2007; 14(2):73.
10. 向春華, 嚴(yán)律南, 林琦遠(yuǎn), 等. 生長激素受體在人肝癌組織中的表達(dá) [Ｊ]. 中國普外基礎(chǔ)與臨床雜志, 2002; 9(4):255.
11. 趙旭, 滕良珠, 辛濤, 等. 腦膜瘤的增殖活性與生長激素受體的表達(dá) [Ｊ]. 中華神經(jīng)外科雜志, 2005; 21(8):508.
12. 張富偉, 孫少川. 生長激素受體在胃癌及其轉(zhuǎn)移淋巴結(jié)組織中的表達(dá) [Ｊ]. 中華普通外科雜志, 2006; 11(5):377.
13. 梁道明， 張毅， 袁勇， 等. 胃腸道惡性腫瘤組織中生長激素受體的表達(dá) [Ｊ]. 昆明醫(yī)學(xué)院學(xué)報(bào)， 2008； 29(3):10.
14. Nagano M, Chastre E, Choquet A, et al. Expression of prolactin and growth hormone receptor genes and their isoforms in the gastrointestinal tract [Ｊ]. Am J Physiol, 1995; 268(3 Pt 1):G431.
15. Wagner K, Hemminki K, Grzybowska E, et al. Polymorphisms in the growth hormone receptor: a case-control study in breast cancer [Ｊ]. Int J Cancer, 2006; 118(11):2903.
16. Tacke J, Bolder U, Herrmann A, et al. Long-term risk of gastrointestinal tumor recurrence after postoperative treatment with recombinant human growth hormone [Ｊ]. JPEN J Parenter Enteral Nutr, 2000; 24(3):140.
17. 〖ＪＰ３〗段體德, 溫先敏, 劉德權(quán), 等. 生長激素聯(lián)合順鉑及絲裂霉素對荷前胃癌小鼠的抑瘤作用研究 [Ｊ]. 云南醫(yī)藥, 2003; 24(4):261.
18. 陳嘉勇, 甘平, 梁道明, 等. 重組人生長激素在體外對人直腸癌細(xì)胞株HR8348增殖的影響 [Ｊ]. 中國普外基礎(chǔ)與臨床雜志, 2003; 10(4):362.
19. Chen JY, Liang DM, Gan P, et al. In vitro effects of recombinant human growth hormone on growth of human gastric cancer cell line BGC823 cells [Ｊ]. World J Gastroenterol, 2004; 10(8):1132.
20. Liang DM, Chen JY, Zhang Y, et al. Effects of recombinant human growth hormone on growth of human gastric carcinoma xenograft model in nude mice [Ｊ]. World J Gastroenterol, 2006; 12(24):3810.
  1. 1. Biolo G, Iscra F, Bosutti A, et al. Growth hormone decreases muscle glutamine production and stimulates protein synthesis in hypercatabolic patients [Ｊ]. Am J Physiol Endocrinol Metab, 2000; 279(2):E323.
  2. 2. Shen XY, Holt RI, Miell JP, et al. Cirrhotic liver expresses low levels of the full-length and truncated growth hormone receptors [Ｊ]. J Clin Endocrinol Metab, 1998; 83(7):2532.
  3. 3. Divisova J, Kuiatse I, Lazard Z, et al. The growth hormone receptor antagonist pegvisomant blocks both mammary gland development and MCF-7 breast cancer xenograft growth [Ｊ]. Breast Cancer Res Treat, 2006; 98(3):315.
  4. 4. 楊小東, 劉福坤, 許哲, 等. 生長激素受體在結(jié)直腸癌中的表達(dá)及其意義 [Ｊ]. 中華胃腸外科雜志, 2005; 8(3):252.
  5. 5. Wu X, Wan M, Li G, et al. Growth hormone receptor overexpression predicts response of rectal cancers to pre-operative radiotherapy [Ｊ]. Eur J Cancer, 2006; 42(7):888.
  6. 6. Scharf JG, Dombrowski F, Ramadori G. The IGF axis and hepatocarcinogenesis [Ｊ]. Mol Pathol, 2001; 54(3):138.
  7. 7. van Garderen E, Schalken JA. Morphogenic and tumorigenic potentials of the mammary growth hormone/growth hormone receptor system [Ｊ]. Mol Cell Endocrinol, 2002; 197(1-2):153.
  8. 8. Weiss-Messer E, Merom O, Adi A, et al. Growth hormone (GH) receptors in prostate cancer: gene expression in human tissues and cell lines and characterization, GH signaling and androgen receptor regulation in LNCaP cells [Ｊ]. Mol Cell Endocrinol, 2004; 220(1-2):109.
  9. 9. 吳曉宇, 許哲, 陳徹, 等. 生長激素受體在結(jié)直腸癌發(fā)生過程中表達(dá)上調(diào) [Ｊ]. 腸外與腸內(nèi)營養(yǎng), 2007; 14(2):73.
  10. 10. 向春華, 嚴(yán)律南, 林琦遠(yuǎn), 等. 生長激素受體在人肝癌組織中的表達(dá) [Ｊ]. 中國普外基礎(chǔ)與臨床雜志, 2002; 9(4):255.
  11. 11. 趙旭, 滕良珠, 辛濤, 等. 腦膜瘤的增殖活性與生長激素受體的表達(dá) [Ｊ]. 中華神經(jīng)外科雜志, 2005; 21(8):508.
  12. 12. 張富偉, 孫少川. 生長激素受體在胃癌及其轉(zhuǎn)移淋巴結(jié)組織中的表達(dá) [Ｊ]. 中華普通外科雜志, 2006; 11(5):377.
  13. 13. 梁道明， 張毅， 袁勇， 等. 胃腸道惡性腫瘤組織中生長激素受體的表達(dá) [Ｊ]. 昆明醫(yī)學(xué)院學(xué)報(bào)， 2008； 29(3):10.
  14. 14. Nagano M, Chastre E, Choquet A, et al. Expression of prolactin and growth hormone receptor genes and their isoforms in the gastrointestinal tract [Ｊ]. Am J Physiol, 1995; 268(3 Pt 1):G431.
  15. 15. Wagner K, Hemminki K, Grzybowska E, et al. Polymorphisms in the growth hormone receptor: a case-control study in breast cancer [Ｊ]. Int J Cancer, 2006; 118(11):2903.
  16. 16. Tacke J, Bolder U, Herrmann A, et al. Long-term risk of gastrointestinal tumor recurrence after postoperative treatment with recombinant human growth hormone [Ｊ]. JPEN J Parenter Enteral Nutr, 2000; 24(3):140.
  17. 17. 〖ＪＰ３〗段體德, 溫先敏, 劉德權(quán), 等. 生長激素聯(lián)合順鉑及絲裂霉素對荷前胃癌小鼠的抑瘤作用研究 [Ｊ]. 云南醫(yī)藥, 2003; 24(4):261.
  18. 18. 陳嘉勇, 甘平, 梁道明, 等. 重組人生長激素在體外對人直腸癌細(xì)胞株HR8348增殖的影響 [Ｊ]. 中國普外基礎(chǔ)與臨床雜志, 2003; 10(4):362.
  19. 19. Chen JY, Liang DM, Gan P, et al. In vitro effects of recombinant human growth hormone on growth of human gastric cancer cell line BGC823 cells [Ｊ]. World J Gastroenterol, 2004; 10(8):1132.
  20. 20. Liang DM, Chen JY, Zhang Y, et al. Effects of recombinant human growth hormone on growth of human gastric carcinoma xenograft model in nude mice [Ｊ]. World J Gastroenterol, 2006; 12(24):3810.