目的 研究肝細(xì)胞移植的臨床應(yīng)用及其最新研究進(jìn)展。方法 對(duì)有關(guān)肝細(xì)胞移植的文獻(xiàn)進(jìn)行綜述
分析。結(jié)果 肝細(xì)胞移植經(jīng)過幾十年的發(fā)展與臨床運(yùn)用,出現(xiàn)了以基因修飾細(xì)胞作為種子細(xì)胞,結(jié)合高分子材料的
皮下移植、包囊化預(yù)處理等新技術(shù)與新進(jìn)展。結(jié)論 隨著肝細(xì)胞移植研究的深入以及基因技術(shù)和高分子材料的運(yùn)
用,肝細(xì)胞移植作為一種治療急、慢性肝病的方法有著廣泛的臨床應(yīng)用前景。
引用本文: 劉世呈,李靖. 肝細(xì)胞移植的研究進(jìn)展. 中國普外基礎(chǔ)與臨床雜志, 2008, 15(2): 109-111. doi: 復(fù)制
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2. | Tanaka K,Soto-Gutierrez A,Navarro-Alvarez N,et al.Functional hepatocyte culture and its application to cell therapies[J].Cell Transplant,2006; 15(10):855. |
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5. | Chen Y,Kobayashi N,Suzuki S,et al.Transplantation of human hepatocytes cultured with deleted variant of hepatocyte growth factor prolongs the survival of mice with acute liver failure[J].Transplantation,2005; 79(10):1378. |
6. | Khan AA,Habeeb A,Parveen N,et al.Peritoneal transplantation of human fetal hepatocytes for the treatment of acute fatty liver of pregnancy:a case report[J].Trop Gastroenterol,2004; 25(3):141. |
7. | Lagasse E,Connors H,Al-Dhalimy M,et al.Purified hematopoietic stem cells can differentiate into hepatocytes in vivo[J].Nat Med,2000; 6(11):1229. |
8. | Auth MK,Woitaschek D,Beste M,et al.Preservation of the synthetic and metabolic capacity of isolated human hepatocytes by coculture with human biliary epithelial cells[J].Liver Transpl,2005; 11(4):410. |
9. | Murasawa S,Asahara T.Gene modified cell transplantation for vascular regeneration[J].Curr Gene Ther,2007; 7(1):1. |
10. | Li J,Li LJ,Cao HC,et al.Establishment of highly differentiated immortalized human hepatocyte line with simian virus 40 large tumor antigen for liver based cell therapy[J].ASAIO J,2005; 51(3):262. |
11. | Mashalova EV,Guha C,Roy-Chowdhury N,et al.Prevention of hepatocyte allograft rejection in rats by transferring adenoviral early region 3 genes into donor cells[J].Hepatology,2007; 45(3):755. |
12. | Yu CH,Chen HL,Chen WT,et al.Portal hemodynamic changes after hepatocyte transplantation in acute hepatic failure[J].J Biomed Sci,2004; 11(6):756. |
13. | Kato K,Onodera K,Sawa M,et al.Effect of hepatocyte growth factor on the proliferation of intrasplenically transplanted hepatocytes in rats[J].Biochem Biophys Res Commun,1996; 222(1):101. |
14. | Ahmad TA,Fujioka H,Eguchi S,et al.Long-term effect of hepatocyte transplantation on fulminant hepatic failure in rats[J].Hepatogastroenterology,2003; 50(50):467. |
15. | Sigot V,Mediavilla MG,Furno G,et al.A simple and effective method to improve intrasplenic rat hepatocyte transplantation[J].Cell Transplant,2004; 13(7-8):775. |
16. | Yokoyama T,Ohashi K,Kuge H,et al.In vivo engineering of metabolically active hepatic tissues in a neovascularized subcutaneous cavity[J].Am J Transplant,2006; 6(1):50. |
17. | Terry C,Dhawan A,Mitry RR,et al.Preincubation of rat and human hepatocytes with cytoprotectants prior to cryopreservation can improve viability and function upon thawing[J].Liver Transpl,2006; 12(1):165. |
18. | Jamal HZ,Weglarz TC,Sandgren EP.Cryopreserved mouse hepatocytes retain regenerative capacity in vivo[J].Gastroenterology,2000; 118(2):390. |
19. | Aleem Khan A,Parveen N,Habeeb MA,et al.Journey from hepatocyte transplantation to hepatic stem cells:a novel treatment strategy for liver diseases[J].Indian J Med Res,2006; 123(5):601. |
20. | Rahman TM,Diakanov I,Selden C,et al.Co-transplantation of encapsulated HepG2 and rat Sertoli cells improves outcome in a thioacetamide induced rat model of acute hepatic failure[J].Transpl Int,2005; 18(8):1001. |
21. | 侯輝,耿小平.肝切除及肝移植術(shù)中缺血預(yù)處理的臨床研究進(jìn)展[J].國際外科學(xué)雜志,2007; 34(2):128. |
22. | Dagher I,Boudechiche L,Branger J,et al.Efficient hepatocyte engraftment in a nonhuman primate model after partial portal vein embolization[J].Transplantation,2006; 82(8):1067. |
23. | Bilir BM,Guinette D,Karrer F,et al.Hepatocyte transplantation in acute liver failure[J].Liver Transpl,2000; 6(1):32. |
24. | Dhawan A,Mitry RR,Hughes RD.Hepatocyte transplantation for liver-based metabolic disorders[J].J Inherit Metab Dis,2006; 29(2-3):431. |
- 1. Berry MN,Friend DS.High-yield preparation of isolated rat liver parenchymal cells:a biochemical and fine structural study[J].J Cell Biol,1969; 43(3):506.
- 2. Tanaka K,Soto-Gutierrez A,Navarro-Alvarez N,et al.Functional hepatocyte culture and its application to cell therapies[J].Cell Transplant,2006; 15(10):855.
- 3. 李曉芳,范昕建,王文雅.人工肝臨床應(yīng)用的研究進(jìn)展[J].西部醫(yī)學(xué),2005; 17(1):70.
- 4. Mazaris EM,Roussos CT,Papalois VE.Hepatocyte transplantation:a review of worldwide clinical developments and experiences[J].Exp Clin Transplant,2005; 3(1):306.
- 5. Chen Y,Kobayashi N,Suzuki S,et al.Transplantation of human hepatocytes cultured with deleted variant of hepatocyte growth factor prolongs the survival of mice with acute liver failure[J].Transplantation,2005; 79(10):1378.
- 6. Khan AA,Habeeb A,Parveen N,et al.Peritoneal transplantation of human fetal hepatocytes for the treatment of acute fatty liver of pregnancy:a case report[J].Trop Gastroenterol,2004; 25(3):141.
- 7. Lagasse E,Connors H,Al-Dhalimy M,et al.Purified hematopoietic stem cells can differentiate into hepatocytes in vivo[J].Nat Med,2000; 6(11):1229.
- 8. Auth MK,Woitaschek D,Beste M,et al.Preservation of the synthetic and metabolic capacity of isolated human hepatocytes by coculture with human biliary epithelial cells[J].Liver Transpl,2005; 11(4):410.
- 9. Murasawa S,Asahara T.Gene modified cell transplantation for vascular regeneration[J].Curr Gene Ther,2007; 7(1):1.
- 10. Li J,Li LJ,Cao HC,et al.Establishment of highly differentiated immortalized human hepatocyte line with simian virus 40 large tumor antigen for liver based cell therapy[J].ASAIO J,2005; 51(3):262.
- 11. Mashalova EV,Guha C,Roy-Chowdhury N,et al.Prevention of hepatocyte allograft rejection in rats by transferring adenoviral early region 3 genes into donor cells[J].Hepatology,2007; 45(3):755.
- 12. Yu CH,Chen HL,Chen WT,et al.Portal hemodynamic changes after hepatocyte transplantation in acute hepatic failure[J].J Biomed Sci,2004; 11(6):756.
- 13. Kato K,Onodera K,Sawa M,et al.Effect of hepatocyte growth factor on the proliferation of intrasplenically transplanted hepatocytes in rats[J].Biochem Biophys Res Commun,1996; 222(1):101.
- 14. Ahmad TA,Fujioka H,Eguchi S,et al.Long-term effect of hepatocyte transplantation on fulminant hepatic failure in rats[J].Hepatogastroenterology,2003; 50(50):467.
- 15. Sigot V,Mediavilla MG,Furno G,et al.A simple and effective method to improve intrasplenic rat hepatocyte transplantation[J].Cell Transplant,2004; 13(7-8):775.
- 16. Yokoyama T,Ohashi K,Kuge H,et al.In vivo engineering of metabolically active hepatic tissues in a neovascularized subcutaneous cavity[J].Am J Transplant,2006; 6(1):50.
- 17. Terry C,Dhawan A,Mitry RR,et al.Preincubation of rat and human hepatocytes with cytoprotectants prior to cryopreservation can improve viability and function upon thawing[J].Liver Transpl,2006; 12(1):165.
- 18. Jamal HZ,Weglarz TC,Sandgren EP.Cryopreserved mouse hepatocytes retain regenerative capacity in vivo[J].Gastroenterology,2000; 118(2):390.
- 19. Aleem Khan A,Parveen N,Habeeb MA,et al.Journey from hepatocyte transplantation to hepatic stem cells:a novel treatment strategy for liver diseases[J].Indian J Med Res,2006; 123(5):601.
- 20. Rahman TM,Diakanov I,Selden C,et al.Co-transplantation of encapsulated HepG2 and rat Sertoli cells improves outcome in a thioacetamide induced rat model of acute hepatic failure[J].Transpl Int,2005; 18(8):1001.
- 21. 侯輝,耿小平.肝切除及肝移植術(shù)中缺血預(yù)處理的臨床研究進(jìn)展[J].國際外科學(xué)雜志,2007; 34(2):128.
- 22. Dagher I,Boudechiche L,Branger J,et al.Efficient hepatocyte engraftment in a nonhuman primate model after partial portal vein embolization[J].Transplantation,2006; 82(8):1067.
- 23. Bilir BM,Guinette D,Karrer F,et al.Hepatocyte transplantation in acute liver failure[J].Liver Transpl,2000; 6(1):32.
- 24. Dhawan A,Mitry RR,Hughes RD.Hepatocyte transplantation for liver-based metabolic disorders[J].J Inherit Metab Dis,2006; 29(2-3):431.