• 四川省瀘州醫(yī)學(xué)院附屬醫(yī)院血管外科（瀘州646000）;

【摘要】目的  探討白細(xì)胞激活及炎癥反應(yīng)在慢性靜脈功能不全中的作用。方法  查閱國內(nèi)、外相關(guān)文獻(xiàn)并進(jìn)行綜述。結(jié)果  白細(xì)胞激活及炎癥反應(yīng)參與靜脈壁和瓣膜重塑，導(dǎo)致靜脈瓣膜功能不全及靜脈曲張的形成。結(jié)論  白細(xì)胞激活及由此引起的炎癥反應(yīng)在慢性靜脈功能不全的發(fā)生、發(fā)展中起重要作用。

引用本文： 文雪剛,何延政,劉勇. 白細(xì)胞激活及炎癥反應(yīng)在慢性靜脈功能不全中的作用. 中國普外基礎(chǔ)與臨床雜志, 2008, 15(3): 227-230. doi: 復(fù)制

1. 29 Bergan JJ. Chronic venous insufficiency and the therapeutic effects of Daflon 500 mg [ J ] . Angiology, 2005; 56 Suppl 1 ∶ S21.
2. 王深明. 下肢深靜脈瓣膜功能不全的外科治療 [J]. 中國普外基礎(chǔ)與臨床雜志， 2006; 13(6)∶629.
3. 王昆, 喬正榮, 時(shí)德. 腓腸肌泵與下肢慢性靜脈功能不全 [J]. 中國普外基礎(chǔ)與臨床雜志， 2002； 9(1)∶249.
4. 喬正榮, 時(shí)德. 下肢慢性靜脈功能不全發(fā)病機(jī)理的臨床研究 [J]. 中國普外基礎(chǔ)與臨床雜志， 2003; 10(3)∶249.
5. 張智輝, 張皓. 白細(xì)胞激活在靜脈疾病中的作用 [J]. 上海醫(yī)學(xué)， 2004; 27(4)∶281.
6. 張智輝, 張皓, 張柏根. 白細(xì)胞激活-慢性靜脈功能不全發(fā)病機(jī)制的近代觀念 [J]. 國外醫(yī)學(xué)·外科學(xué)分冊， 2003; 30(5)∶262.
7. Fukuda S, Yasu T, Predescu DN, et al. Mechanisms for regulation of fluid shear stress response in circulating leukocytes [J]. Circ Res, 2000; 86(1)∶E13.
8. Veraart JC. Chronic venous insufficiency [J]. Ned Tijdschr Ge-neeskd, 2002; 146(5)∶199.
9. Coleridge Smith PD, Thomas P, Scurr JH, et al. Causes of venous ulceration: a new hypothesis [J]. Br Med J (Clin Res Ed), 1988; 296(6638)∶1726.
10. Takase S, Delano FA, Lerond L, et al. Inflammation in chronic venous insufficiency. Is the problem insurmountable? [J]. J Vasc Res, 1999; 36 Suppl 1∶3.
11. Schmid-Schonbein GW, Takase S, Bergan JJ. New advances in the understanding of the pathophysiology of chronic venous insufficiency [J]. Angiology, 2001; 52 Suppl 1∶S27.
12. Saharay M, Shields DA, Porter JB, et al. Leukocyte activity in the microcirculation of the leg in patients with chronic venous disease [J]. J Vasc Surg， 1997； 26(2)∶265.
13. Junger M, Friedrich B, Hahn J, et al. Dysregulated L-selectin expression on lymphocytes in patients with chronic venous insufficiency [J]. Clin Hemorheol Microcirc, 2001; 25(1)∶21.
14. 張嵐, 張柏根. 下肢慢性靜脈功能不全與炎癥反應(yīng)及細(xì)胞免疫 [J]. 中華外科雜志, 2005; 43(13)∶896.
15. Sayer GL, Smith PD. Immunocytochemical characterisation of the inflammatory cell infiltrate of varicose veins [J]. Eur J Vasc Endovasc Surg, 2004; 28(5)∶479.
16. Stvrtinova V, Jahnova E, Weissova S, et al. Inflammatory mechanisms involving neutrophils in chronic venous insufficiency of lower limbs [J]. Bratisl Lek Listy, 2001; 102(5)∶235.
17. Saharay M, Shields DA, Georgiannos SN, et al. Endothelial activation in patients with chronic venous disease [J]. Eur J Vasc Endovasc Surg, 1998; 15(4)∶342.
18. Smith PD. Neutrophil activation and mediators of inflammation in chronic venous insufficiency [J]. J Vasc Res, 1999; 36 Suppl 1∶24.
19. Takase S, Pascarella L, Lerond L, et al. Venous hypertension, inflammation and valve remodeling [J]. Eur J Vasc Endovasc Surg, 2004; 28(5)∶484.
20. Nicolaides AN. Chronic venous disease and the leukocyte-endothelium interaction: from symptoms to ulceration [J]. Angiology， 2005； 56 Suppl 1∶S11.
21. Michiels C, Arnould T, Thibaut-Vercruyssen R, et al. Perfused human saphenous veins for the study of the origin of varicose veins, role of the endothelium and hypoxia [J]. Int Angiol, 1997; 16(2)∶134.
22. Takase S, Pascarella L, Bergan JJ, et al. Hypertension-induced venous valve remodeling [J]. J Vasc Surg, 2004; 39(6)∶1329.
23. Pascarella L, Penn A, Schmid-Schonbein GW. Venous hypertension and the inflammatory cascade: major manifestations and trigger mechanisms [J]. Angiology, 2005; 56 Suppl 1∶S3.
24. Pascarella L, Schmid-Schonbein GW, Bergan J. An animal mo-del of venous hypertension: the role of inflammation in venous valve failure [J]. J Vasc Surg, 2005; 41(2)∶303.
25. Takase S, Bergan JJ, Schmid-Schonbein G. Expression of adhesion molecules and cytokines on saphenous veins in chronic venous insufficiency [J]. Ann Vasc Surg, 2000; 14(5)∶427.
26. Ono T, Bergan JJ, Schmid-Schonbein GW, et al. Monocyte infiltration into venous valves [J]. J Vasc Surg, 1998; 27(1)∶158.
27. Smith PD. Update on chronic-venous-insufficiency-induced inflammatory processes [J]. Angiology, 2001; 52 Suppl 1∶S35.
28. Coleridge Smith PD. Deleterious effects of white cells in the course of skin damage in CVI [J]. Int Angiol, 2002; 21(2 Suppl 1)∶26.
29. Sándor T. Pathomechanism of chronic venous insufficiency and leg ulcer [J]. Acta Physiol Hung, 2004; 91(2)∶131.
  1. 1. 29 Bergan JJ. Chronic venous insufficiency and the therapeutic effects of Daflon 500 mg [ J ] . Angiology, 2005; 56 Suppl 1 ∶ S21.
  2. 2. 王深明. 下肢深靜脈瓣膜功能不全的外科治療 [J]. 中國普外基礎(chǔ)與臨床雜志， 2006; 13(6)∶629.
  3. 3. 王昆, 喬正榮, 時(shí)德. 腓腸肌泵與下肢慢性靜脈功能不全 [J]. 中國普外基礎(chǔ)與臨床雜志， 2002； 9(1)∶249.
  4. 4. 喬正榮, 時(shí)德. 下肢慢性靜脈功能不全發(fā)病機(jī)理的臨床研究 [J]. 中國普外基礎(chǔ)與臨床雜志， 2003; 10(3)∶249.
  5. 5. 張智輝, 張皓. 白細(xì)胞激活在靜脈疾病中的作用 [J]. 上海醫(yī)學(xué)， 2004; 27(4)∶281.
  6. 6. 張智輝, 張皓, 張柏根. 白細(xì)胞激活-慢性靜脈功能不全發(fā)病機(jī)制的近代觀念 [J]. 國外醫(yī)學(xué)·外科學(xué)分冊， 2003; 30(5)∶262.
  7. 7. Fukuda S, Yasu T, Predescu DN, et al. Mechanisms for regulation of fluid shear stress response in circulating leukocytes [J]. Circ Res, 2000; 86(1)∶E13.
  8. 8. Veraart JC. Chronic venous insufficiency [J]. Ned Tijdschr Ge-neeskd, 2002; 146(5)∶199.
  9. 9. Coleridge Smith PD, Thomas P, Scurr JH, et al. Causes of venous ulceration: a new hypothesis [J]. Br Med J (Clin Res Ed), 1988; 296(6638)∶1726.
  10. 10. Takase S, Delano FA, Lerond L, et al. Inflammation in chronic venous insufficiency. Is the problem insurmountable? [J]. J Vasc Res, 1999; 36 Suppl 1∶3.
  11. 11. Schmid-Schonbein GW, Takase S, Bergan JJ. New advances in the understanding of the pathophysiology of chronic venous insufficiency [J]. Angiology, 2001; 52 Suppl 1∶S27.
  12. 12. Saharay M, Shields DA, Porter JB, et al. Leukocyte activity in the microcirculation of the leg in patients with chronic venous disease [J]. J Vasc Surg， 1997； 26(2)∶265.
  13. 13. Junger M, Friedrich B, Hahn J, et al. Dysregulated L-selectin expression on lymphocytes in patients with chronic venous insufficiency [J]. Clin Hemorheol Microcirc, 2001; 25(1)∶21.
  14. 14. 張嵐, 張柏根. 下肢慢性靜脈功能不全與炎癥反應(yīng)及細(xì)胞免疫 [J]. 中華外科雜志, 2005; 43(13)∶896.
  15. 15. Sayer GL, Smith PD. Immunocytochemical characterisation of the inflammatory cell infiltrate of varicose veins [J]. Eur J Vasc Endovasc Surg, 2004; 28(5)∶479.
  16. 16. Stvrtinova V, Jahnova E, Weissova S, et al. Inflammatory mechanisms involving neutrophils in chronic venous insufficiency of lower limbs [J]. Bratisl Lek Listy, 2001; 102(5)∶235.
  17. 17. Saharay M, Shields DA, Georgiannos SN, et al. Endothelial activation in patients with chronic venous disease [J]. Eur J Vasc Endovasc Surg, 1998; 15(4)∶342.
  18. 18. Smith PD. Neutrophil activation and mediators of inflammation in chronic venous insufficiency [J]. J Vasc Res, 1999; 36 Suppl 1∶24.
  19. 19. Takase S, Pascarella L, Lerond L, et al. Venous hypertension, inflammation and valve remodeling [J]. Eur J Vasc Endovasc Surg, 2004; 28(5)∶484.
  20. 20. Nicolaides AN. Chronic venous disease and the leukocyte-endothelium interaction: from symptoms to ulceration [J]. Angiology， 2005； 56 Suppl 1∶S11.
  21. 21. Michiels C, Arnould T, Thibaut-Vercruyssen R, et al. Perfused human saphenous veins for the study of the origin of varicose veins, role of the endothelium and hypoxia [J]. Int Angiol, 1997; 16(2)∶134.
  22. 22. Takase S, Pascarella L, Bergan JJ, et al. Hypertension-induced venous valve remodeling [J]. J Vasc Surg, 2004; 39(6)∶1329.
  23. 23. Pascarella L, Penn A, Schmid-Schonbein GW. Venous hypertension and the inflammatory cascade: major manifestations and trigger mechanisms [J]. Angiology, 2005; 56 Suppl 1∶S3.
  24. 24. Pascarella L, Schmid-Schonbein GW, Bergan J. An animal mo-del of venous hypertension: the role of inflammation in venous valve failure [J]. J Vasc Surg, 2005; 41(2)∶303.
  25. 25. Takase S, Bergan JJ, Schmid-Schonbein G. Expression of adhesion molecules and cytokines on saphenous veins in chronic venous insufficiency [J]. Ann Vasc Surg, 2000; 14(5)∶427.
  26. 26. Ono T, Bergan JJ, Schmid-Schonbein GW, et al. Monocyte infiltration into venous valves [J]. J Vasc Surg, 1998; 27(1)∶158.
  27. 27. Smith PD. Update on chronic-venous-insufficiency-induced inflammatory processes [J]. Angiology, 2001; 52 Suppl 1∶S35.
  28. 28. Coleridge Smith PD. Deleterious effects of white cells in the course of skin damage in CVI [J]. Int Angiol, 2002; 21(2 Suppl 1)∶26.
  29. 29. Sándor T. Pathomechanism of chronic venous insufficiency and leg ulcer [J]. Acta Physiol Hung, 2004; 91(2)∶131.