目的 探討低位直腸癌保留神經(jīng)的腹膜外側(cè)方擴大清掃對患者術(shù)后生存率、排尿功能和性功能的影響。方法 回顧性分析我院1996年1月至2000年6月期間收治的392例進展期低位直腸癌實施保留神經(jīng)的根治性切除術(shù)患者的臨床資料,其中行腹腔內(nèi)清掃173例,腹腔內(nèi)加腹膜外側(cè)方清掃219例,2組患者在年齡、性別、浸潤腸壁深度及腫瘤病理組織學(xué)類型方面差異無統(tǒng)計學(xué)意義。結(jié)果 腹腔內(nèi)加腹膜外側(cè)方清掃組側(cè)方淋巴結(jié)轉(zhuǎn)移率為17.8%(39/219),側(cè)方盆壁非連續(xù)性癌灶轉(zhuǎn)移率為5.9%(13/219)。術(shù)后發(fā)生排尿功能障礙: 腹腔內(nèi)清掃組7例(4.0%),腹腔內(nèi)加腹膜外側(cè)方清掃組113例(51.6%),2組比較差異有統(tǒng)計學(xué)意義(P<0.01); 性功能障礙: 腹腔內(nèi)清掃組93例男性患者中有12例(12.9%),腹腔內(nèi)加腹膜外側(cè)方清掃組119例男性患者中有62例(52.1%),2組比較差異有統(tǒng)計學(xué)意義(P<0.01); 局部復(fù)發(fā)率: 腹腔內(nèi)清掃組為16.2%(28/173),腹腔內(nèi)加腹膜外側(cè)方清掃組為9.6%(21/219),2組比較差異有統(tǒng)計學(xué)意義(P<0.05); 5年生存率: 腹腔內(nèi)清掃組為49.1%(85/173),腹腔內(nèi)加腹膜外側(cè)方清掃組為59.4%(130/219),2組比較差異有統(tǒng)計學(xué)意義(P<0.05)。結(jié)論 低位直腸癌保留神經(jīng)的腹膜外側(cè)方擴大清掃,可以減少局部復(fù)發(fā),提高患者5年生存率,但也會影響患者術(shù)后排尿和男性性機能。
引用本文: 左明,劉寶善,徐琳,燕錦,劉超. 低位直腸癌保留神經(jīng)的腹膜外側(cè)方擴大清掃的效果分析. 中國普外基礎(chǔ)與臨床雜志, 2006, 13(5): 568-572. doi: 復(fù)制
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7. | Enker WE. Total mesorectal excision with sphincter and autonomic nerve preservation in the treatment of rectal cancer [J]. Curr Tech Gen Sury, 1996; 5(1)∶1. |
8. | Hojo K, Vernava AM 3rd, Sugihara K, et al. Preservation of urine voiding and sexual function after rectal cancer surgery [J]. Dis Colon Rectum, 1991; 34(7)∶532. |
9. | Kinn AC, Ohman U. Bladder and sexual function after surgery for rectal cancer [J]. Dis Colon Rectum, 1986; 29(1)∶43. |
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11. | 森武生. 自律神經(jīng)全溫存を伴う側(cè)方廓清 [J]. 消化器外科, 2000; 23(7)∶1253. |
12. | Hojo K, Sawada T, Moriya Y. An analysis of survival and voiding, sexual function after wide iliopelvic lymphadenectomy in patients with carcinoma of the rectum, compared with conventional lymphadenectomy [J]. Dis Colon Rectum, 1989; 32(2)∶128. |
13. | Eickenberg HU, Amin M, Klompus W, et al. Urologic complications following abdominoperineal resection [J]. J Urol, 1976; 115(2)∶180. |
14. | Maas CP, Moriya Y, Steup WH, et al. Radical and nerve-preserving surgery for rectal cancer in The Netherlands: a prospective study on morbidity and functional outcome [J]. Br J Surg, 1998; 85(1)∶92. |
15. | Enker WE, Havenga K, Polyak T, et al. Abdominoperineal resection via total mesorectal excision and autonomic nerve preservation for low rectal cancer [J]. World J Surg, 1997; 21(7)∶715. |
16. | 小野正人. 下部直腸癌における側(cè)方廓清は標準的治療であるべ きか [J]. 外科, 2000; 62(8)∶927. |
17. | Takahashi T, Ueno M, Azekura K, et al. Lateral node dissection and total mesorectal excision for rectal cancer [J]. Dis Colon Rectum, 2000; 43(10 Suppl)∶S59. |
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- 1. Stearns MW Jr, Deddish MR. Five-year results of abdominopelvic lymph node dissection for carcinoma of the rectum [J]. Dis Colon Rectum, 1959; 2(2)∶169.
- 2. 高橋孝. 直腸癌根治術(shù)式の變遷と最新の話題 [J]. 消化器外科, 1998; 21(3)∶271.
- 3. Heald RJ, Husband EM, Ryall RD. The mesorectum in rectal cancer surgery-the clue to pelvic recurrence? [J]. Br J Surg, 1982; 69(10)∶613.
- 4. 董新舒, 李志高, 崔濱濱, 等. 低位直腸癌側(cè)方淋巴結(jié)清掃的臨床意義 [J]. 中國普外基礎(chǔ)與臨床雜志, 2003; 10(2)∶103.
- 5. 加藤知行, 森武生. 直腸癌側(cè)方廓清の是非を間う [J]. 外科, 2000; 62(8)∶924.
- 6. 森田隆幸, 中村文彥, 遠藤正章, 他. 腹膜外ァプローチに等る進行下部直腸癌のリンベ節(jié)廓清 [J]. 手術(shù), 1995; 49(8)∶1065.
- 7. Enker WE. Total mesorectal excision with sphincter and autonomic nerve preservation in the treatment of rectal cancer [J]. Curr Tech Gen Sury, 1996; 5(1)∶1.
- 8. Hojo K, Vernava AM 3rd, Sugihara K, et al. Preservation of urine voiding and sexual function after rectal cancer surgery [J]. Dis Colon Rectum, 1991; 34(7)∶532.
- 9. Kinn AC, Ohman U. Bladder and sexual function after surgery for rectal cancer [J]. Dis Colon Rectum, 1986; 29(1)∶43.
- 10. Moriya Y, Sugihara K, Akasu T, et al. Nerve-sparing surgery with lateral node dissection for advanced lower rectal cancer [J]. Eur J Cancer, 1995; 31A(7-8)∶1229.
- 11. 森武生. 自律神經(jīng)全溫存を伴う側(cè)方廓清 [J]. 消化器外科, 2000; 23(7)∶1253.
- 12. Hojo K, Sawada T, Moriya Y. An analysis of survival and voiding, sexual function after wide iliopelvic lymphadenectomy in patients with carcinoma of the rectum, compared with conventional lymphadenectomy [J]. Dis Colon Rectum, 1989; 32(2)∶128.
- 13. Eickenberg HU, Amin M, Klompus W, et al. Urologic complications following abdominoperineal resection [J]. J Urol, 1976; 115(2)∶180.
- 14. Maas CP, Moriya Y, Steup WH, et al. Radical and nerve-preserving surgery for rectal cancer in The Netherlands: a prospective study on morbidity and functional outcome [J]. Br J Surg, 1998; 85(1)∶92.
- 15. Enker WE, Havenga K, Polyak T, et al. Abdominoperineal resection via total mesorectal excision and autonomic nerve preservation for low rectal cancer [J]. World J Surg, 1997; 21(7)∶715.
- 16. 小野正人. 下部直腸癌における側(cè)方廓清は標準的治療であるべ きか [J]. 外科, 2000; 62(8)∶927.
- 17. Takahashi T, Ueno M, Azekura K, et al. Lateral node dissection and total mesorectal excision for rectal cancer [J]. Dis Colon Rectum, 2000; 43(10 Suppl)∶S59.
- 18. Moreira LF, Hizuta A, Iwagaki H, et al. Lateral lymph node dissection for rectal carcinoma below the peritoneal reflection [J]. Br J Surg, 1994; 81(2)∶293.